PMID: 2493535Jan 1, 1989Paper

Reactive airways dysfunction syndrome presenting as a reversible restrictive defect

Lung
R Gilbert, J H Auchincloss

Abstract

A 25-year-old farm worker developed acute bronchopneumonia after heavy exposure to a respiratory irritant in a silo. He recovered from the acute episode but then experienced chronic dyspnea and fatigue. Pulmonary function testing showed small lung volumes with a normal ratio of 1 s forced expiratory volume/forced vital capacity (restrictive defect). This defect improved markedly with bronchodilator treatment and changed to a mixed obstructive/restrictive defect with methacholine challenge. We believe that this is an example of the reactive airways dysfunction syndrome manifested by a restrictive rather than obstructive defect. Constriction of airways at the bronchiole or alveolar duct level is the most likely cause of the syndrome.

References

Mar 22, 1979·The New England Journal of Medicine·W M CorraoR S Irwin
Sep 1, 1976·Annals of Internal Medicine·D W HudgelJ Souhrada
Sep 1, 1986·Archives of Internal Medicine·R Gilbert, J H Auchincloss
Sep 1, 1985·Archives of Internal Medicine·R Gilbert, J H Auchincloss

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Citations

Dec 1, 1995·Toxicology Letters·S M Brooks
Nov 1, 1991·The American Review of Respiratory Disease·D G Kern
Aug 24, 2013·Journal of Occupational and Environmental Medicine·Stuart M Brooks
Mar 1, 1993·Chest·D A Kaminsky, C G Irvin
Sep 12, 2013·BioMed Research International·Jean I KeddissiGary T Kinasewitz
Jun 27, 2006·Respiratory Medicine·Albert Miller, Agnes Palecki
Jun 1, 1996·Chest·W M Alberts, G A do Pico

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