Reactive Astrocytes in Brain Metastasis

Frontiers in Oncology
David WasilewskiManuel Valiente

Abstract

Brain metastasis, the secondary growth of malignant cells within the central nervous system (CNS), exceeds the incidence of primary brain tumors (i.e., gliomas) by tenfold and are seemingly on the rise owing to the emergence of novel targeted therapies that are more effective in controlling extracranial disease relatively to intracranial lesions. Despite the fact that metastasis to the brain poses a unmet clinical problem, with afflicted patients carrying significant morbidity and a fatal prognosis, our knowledge as to how metastatic cells manage to adapt to the tissue environment of the CNS remains limited. Answering this question could pave the way for novel and more specific therapeutic modalities in brain metastasis by targeting the specific makeup of the brain metastatic niche. In regard to this, astrocytes have emerged as the major host cell type that cancer cells encounter and interact with during brain metastasis formation. Similarly to other CNS disorders, astrocytes become reactive and respond to the presence of cancer cells by changing their phenotype and significantly influencing the outcome of disseminated cancer cells within the CNS. Here, we summarize the current knowledge on the contribution of reactive astrocyt...Continue Reading

References

Jun 1, 1980·The Journal of Cell Biology·K D McCarthy, J de Vellis
Oct 20, 1998·Oncogene·M KatoI Nakashima
Nov 26, 2002·Journal of Neuroimmunology·Sophie Desplat-JégoJosé Boucraut
Jan 22, 2004·Nature Reviews. Neuroscience·Jerry Silver, Jared H Miller
Oct 11, 2005·Journal of Neuro-oncology·Igor T Gavrilovic, Jerome B Posner
May 17, 2007·Clinical & Experimental Metastasis·Odete MendesGeorge Stoica
Mar 28, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nancy Ann OberheimMaiken Nedergaard
Apr 25, 2008·Nature Reviews. Cancer·H Llewelyn Roderick, Simon J Cook
Jul 24, 2008·Clinical & Experimental Metastasis·Daniel P FitzgeraldPatricia S Steeg
May 8, 2009·Nature·Paula D BosJoan Massagué
Jul 30, 2009·Cancer Research·Elizabeth A MaherSuresh Mohla
Sep 29, 2009·Trends in Neurosciences·Michael V Sofroniew
Dec 22, 2009·Nature Medicine·Yvonne KienastFrank Winkler
Jan 21, 2010·Nature Reviews. Neuroscience·Christian GiaumeNathalie Rouach
Feb 24, 2010·Nature Reviews. Molecular Cell Biology·Simona NegriniThanos D Halazonetis
Apr 13, 2010·The American Journal of Pathology·Mihaela Lorger, Brunhilde Felding-Habermann
Sep 9, 2010·Neoplasia : an International Journal for Oncology Research·Qingtang LinIsaiah J Fidler
Nov 18, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Brunilde GrilPatricia S Steeg
Dec 15, 2010·Translational Oncology·Emily C BrantleyIsaiah J Fidler
Mar 11, 2011·Neoplasia : an International Journal for Oncology Research·Sun-Jin KimIsaiah J Fidler
Apr 8, 2011·Nature Reviews. Cancer·Patricia S SteegQuentin R Smith
Apr 14, 2011·Nature Reviews. Clinical Oncology·April F EichlerRakesh K Jain
Aug 13, 2011·Stroke; a Journal of Cerebral Circulation·Issei S ShimadaJeffrey L Spees
May 4, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jennifer L ZamanianBen A Barres
Jun 30, 2012·Science·Hui-Hsin TsaiDavid H Rowitch
Feb 7, 2013·Nature Reviews. Neuroscience·Javier DeFelipeGiorgio A Ascoli
Apr 10, 2013·Neuroscience Letters·Miaomiao JinZhong Chen
Apr 16, 2013·The American Journal of Pathology·Brunilde GrilFernando Vidal-Vanaclocha
Apr 19, 2013·Neuro-oncology·Yan LiuHideho Okada
May 8, 2013·Pigment Cell & Melanoma Research·Amr MorsiYoussef Z Wadghiri
Aug 2, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ina B WannerMichael V Sofroniew

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Citations

May 14, 2020·Cancer Metastasis Reviews·Mari HosonagaYoshimi Arima
Aug 8, 2020·International Journal of Cancer. Journal International Du Cancer·Sivan Izraely, Isaac P Witz
Jun 20, 2019·International Journal of Cancer. Journal International Du Cancer·Tzlil Gener LahavNeta Erez
Aug 16, 2019·Cellular and Molecular Neurobiology·Takashi FujimotoTakayuki Matsuo
Aug 10, 2019·Frontiers in Immunology·Michael SchulzLisa Sevenich
Feb 16, 2020·Molecular Cancer·Ranjana K KanchanMohd W Nasser
Jul 8, 2018·World Journal of Urology·Eliane Gouvêa de Oliveira BarrosAntonio Palumbo
Jul 10, 2020·Cancer Research·Manuel ValienteFrank Winkler
Dec 3, 2020·Frontiers in Oncology·Tianhao ZhuSibo Zhu
Apr 28, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Rama Rao MallaVenkata Ramesh Dasari
Mar 7, 2021·Molecular and Cellular Endocrinology·Eliane Gouvêa de Oliveira-BarrosLuiz Eurico Nasciutti
May 13, 2021·Seminars in Cancer Biology·Andrea R Lim, Cyrus M Ghajar
Jul 14, 2021·Nature Reviews. Clinical Oncology·Patricia S Steeg
Aug 27, 2021·Current Oncology·Terence Teixeira DuarteRui Manuel Reis

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NCT01499251
NCT02429570

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