Reactive astrocytic S1P3 signaling modulates the blood-tumor barrier in brain metastases

Nature Communications
Brunilde GrilPatricia S Steeg

Abstract

Brain metastases are devastating complications of cancer. The blood-brain barrier (BBB), which protects the normal brain, morphs into an inadequately characterized blood-tumor barrier (BTB) when brain metastases form, and is surrounded by a neuroinflammatory response. These structures contribute to poor therapeutic efficacy by limiting drug uptake. Here, we report that experimental breast cancer brain metastases of low- and high permeability to a dextran dye exhibit distinct microenvironmental gene expression patterns. Astrocytic sphingosine-1 phosphate receptor 3 (S1P3) is upregulated in the neuroinflammatory response of the highly permeable lesions, and is expressed in patients' brain metastases. S1P3 inhibition functionally tightens the BTB in vitro and in vivo. S1P3 mediates its effects on BTB permeability through astrocytic secretion of IL-6 and CCL2, which relaxes endothelial cell adhesion. Tumor cell overexpression of S1P3 mimics this pathway, enhancing IL-6 and CCL-2 production and elevating BTB permeability. In conclusion, neuroinflammatory astrocytic S1P3 modulates BTB permeability.

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Dec 22, 2019·International Journal of Molecular Sciences·Eurydice AngeliGuilhem Bousquet
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Datasets Mentioned

BETA
GSE112776

Methods Mentioned

BETA
laser capture microdissection
fluorescence microscopy
Chips
column chromatography
NMR
ELISA
Assay

Software Mentioned

Zeiss Axioskop Axiovision4 ©
StudyLog
Matrix2png
ImageJ
Ingenuity®
Graphpad Prism
Zeiss
SPSS
Illustrator®
ZEN

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