Reactive community-based self-administered treatment against residual malaria transmission: study protocol for a randomized controlled trial

Trials
Joseph OkebeUmberto D'Alessandro

Abstract

Systematic treatment of all individuals living in the same compound of a clinical malaria case may clear asymptomatic infections and possibly reduce malaria transmission, where this is focal. High and sustained coverage is extremely important and requires active community engagement. This study explores a community-based approach to treating malaria case contacts. This is a cluster-randomized trial to determine whether, in low-transmission areas, treating individuals living in the same compound of a clinical malaria case with dihydroartemisinin-piperaquine can reduce parasite carriage and thus residual malaria transmission. Treatment will be administered through the local health system with the approach of encouraging community participation designed and monitored through formative research. The trial goal is to show that this approach can reduce in intervention villages the prevalence of Plasmodium falciparum infection toward the end of the malaria transmission season. Adherence and cooperation of the local communities are critical for the success of mass treatment campaigns aimed at reducing malaria transmission. By exploring community perceptions of the changing trends in malaria burden, existing health systems, and reaction...Continue Reading

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Citations

Jul 6, 2019·Malaria Journal·Felipe Leão Gomes MurtaMarcus Vinícius Guimarães Lacerda
Jan 20, 2021·Scientific Reports·Fatou JaitehKoen Peeters Grietens
Mar 16, 2021·Frontiers in Public Health·Fatou JaitehKoen Peeters Grietens

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Methods Mentioned

BETA
MDA

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OpenClinica
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Stata

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