PMID: 8291658Feb 1, 1994

Reactive eosinophilic pulmonary vascular infiltration in patients with spontaneous pneumothorax

The American Journal of Surgical Pathology
E LunaJ Kleinerman

Abstract

Prominent nonnecrotizing eosinophilic inflammation of muscular pulmonary arteries was seen in resected lung tissue from two patients with spontaneous pneumothorax. Other histologic features included reactive eosinophilic pleuritis (REP) and fibrobullous disease. Eosinophilic vascular infiltration was not contiguous to REP. In neither patient was there a specific and recognized cause of eosinophilic vasculitis. Both patients are without pulmonary symptoms 1 and 4 years after pneumothorax. Eosinophilic vascular infiltration initially suggested the diagnosis of allergic angiitis or pulmonary eosinophilic granuloma. These diagnoses were excluded by clinical and morphologic data. We subsequently reviewed 30 cases of lung tissue resected from patients with pneumothorax and found REP in 18 patients (60%) and mild pulmonary vascular and perivascular eosinophilia in five patients (17%). REP was present in all cases with eosinophilic vascular infiltration. We conclude that this eosinophilic vascular lesion is an unusual reaction in patients with REP and pneumothorax. Occasionally this lesion mimics allergic angiitis or eosinophilic granuloma. The pathogenesis is probably related to vascular transport of eosinophils to the injured pleural...Continue Reading

References

Apr 7, 2009·Indian Journal of Pediatrics·Nishith Kumar JetleyAbdul Lateef Softha
Feb 6, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Konstantin ShiloTeri J Franks
Sep 27, 2007·The American Journal of Surgical Pathology·Aashiyana KoreishiJoseph Misdraji
Jan 31, 2014·Archives of Pathology & Laboratory Medicine·Frank SchneiderKevin O Leslie
May 10, 2002·Pediatric Pulmonology·Bernhard ReschWilhelm D Müller
Nov 9, 2000·American Journal of Clinical Pathology·A L Katzenstein
Jan 6, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S A Yousem

Related Concepts

Eosinophil
Pulmonary Alveolar Structure
Churg-Strauss Syndrome
Immunocytochemistry
Pulmonary Artery Structure
Vascular Diseases
Lobar Bronchus Structure
Eosinophilia
Pneumothorax
Pleurisy

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