Reactive Glia Inflammatory Signaling Pathways and Epilepsy.

International Journal of Molecular Sciences
Pascual Sanz, Maria Adelaida Garcia-Gimeno

Abstract

Neuroinflammation and epilepsy are interconnected. Brain inflammation promotes neuronal hyper-excitability and seizures, and dysregulation in the glia immune-inflammatory function is a common factor that predisposes or contributes to the generation of seizures. At the same time, acute seizures upregulate the production of pro-inflammatory cytokines in microglia and astrocytes, triggering a downstream cascade of inflammatory mediators. Therefore, epileptic seizures and inflammatory mediators form a vicious positive feedback loop, reinforcing each other. In this work, we have reviewed the main glial signaling pathways involved in neuroinflammation, how they are affected in epileptic conditions, and the therapeutic opportunities they offer to prevent these disorders.

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Citations

Dec 17, 2020·Frontiers in Neurology·Quirijn P VerhoogErwin A van Vliet
Jan 8, 2021·Journal of Neuroinflammation·Kuriko Kagitani-ShimonoMasako Taniike
Jan 12, 2021·Frontiers in Neuroscience·Shuang ChenQifu Li
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Apr 4, 2021·International Journal of Molecular Sciences·Tomasz BoczekLudmila Zylinska
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Aug 28, 2021·International Journal of Molecular Sciences·José L Zugaza
Oct 26, 2021·Frontiers in Pharmacology·Muhammad Y Al-ShorbagyDalia M El-Tanbouly
Nov 10, 2021·Molecular Biology Reports·Shubham VishwakarmaThakur Gurjeet Singh

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