Reactive oxygen species-activated nanomaterials as theranostic agents

Nanomedicine
Kye S KimPeter M Kang

Abstract

Reactive oxygen species (ROS) are generated from the endogenous oxidative metabolism or from exogenous pro-oxidant exposure. Oxidative stress occurs when there is excessive production of ROS, outweighing the antioxidant defense mechanisms which may lead to disease states. Hydrogen peroxide (H2O2) is one of the most abundant and stable forms of ROS, implicated in inflammation, cellular dysfunction and apoptosis, which ultimately lead to tissue and organ damage. This review is an overview of the role of ROS in different diseases. We will also examine ROS-activated nanomaterials with emphasis on hydrogen peroxide, and their potential medical implications. Further development of the biocompatible, stimuli-activated agent responding to disease causing oxidative stress, may lead to a promising clinical use.

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H KinouchiP H Chan
Oct 1, 1994·The Journal of Clinical Investigation·R A GottliebR L Engler
Jan 23, 1999·Free Radical Biology & Medicine·A J Kowaltowski, A E Vercesi
Jun 13, 2000·Circulation Research·P M Kang, S Izumo
Aug 18, 2000·Free Radical Biology & Medicine·E A PodrezS L Hazen
Dec 20, 2000·The Journal of Experimental Medicine·B van der LooT F Lüscher
Oct 20, 2001·Redox Report : Communications in Free Radical Research·W H Koppenol
Nov 24, 2001·The Journal of Biological Chemistry·Renata ColavittiTommaso Galeotti
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Jul 13, 2002·Journal of Cellular Physiology·Jennifer L Martindale, Nikki J Holbrook
Jul 19, 2002·Cardiovascular Research·Tohru FukaiDavid G Harrison
Sep 25, 2002·Neurobiology of Disease·Elena TamagnoMassimo Tabaton
Nov 7, 2002·Free Radical Biology & Medicine·Cristina CecchiGianfranco Liguri
Nov 26, 2002·Free Radical Biology & Medicine·Anup RamachandranVictor Darley-Usmar
Mar 21, 2003·The American Journal of Cardiology·Jay W Heinecke
Oct 9, 2003·The EMBO Journal·Nick R LeslieC Peter Downes
Feb 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Eric M BlalockPhilip W Landfield
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rena LiYong Shen
Sep 8, 2004·Neurobiology of Disease·Akihiko NunomuraGeorge Perry
Dec 30, 2004·Journal of Molecular and Cellular Cardiology·Susan E LogueRoberta A Gottlieb
Mar 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Stephen J Nicholls, Stanley L Hazen
Jan 25, 2006·Chemico-biological Interactions·M ValkoM Mazur
Mar 15, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sai T ReddyMelody A Swartz
Mar 29, 2006·Biochimica Et Biophysica Acta·Gerd P BienertThomas P Jahn
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
Sep 22, 2006·Antioxidants & Redox Signaling·Priya RanjanNicholas H Heintz
Nov 16, 2006·The Journal of Biological Chemistry·Gerd P BienertThomas P Jahn
Feb 20, 2007·Current Drug Targets. Inflammation and Allergy·William MacNee
Apr 17, 2007·Molecular Cell·Elizabeth A VealBrian A Morgan
May 25, 2007·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·M JohannsenS A Loening
Aug 21, 2007·Nature Materials·Dongwon LeeNiren Murthy

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Citations

Feb 28, 2017·Macromolecular Rapid Communications·Zhengyu DengShiyong Liu
Oct 11, 2017·Antioxidants & Redox Signaling·Sterling B GlassXiuling Lu
Nov 7, 2019·Nanomaterials·Ioana-Andreea Turin-MoleavinMariana Pinteala
Jan 29, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Koichiro MinamiStefan G Tullius
Jul 14, 2020·Experimental Dermatology·Anca SindrilaruDiana Crisan
Mar 1, 2017·Nanomedicine·Madaswamy S MuthuMatte Kasi Viswanadh
Apr 8, 2020·Frontiers in Bioengineering and Biotechnology·Chen-Wen LiWan-Liang Lu
Sep 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·David AzriaEmmanuel Belamie
Jun 15, 2017·Scientific Reports·Andrey V RomanyukNickolay S Melik-Nubarov
Jul 31, 2020·Materials·Mariana PintealaRadu D Rusu
Sep 6, 2020·Bioengineering·Pasquale Marrazzo, Cian O'Leary
Aug 21, 2020·International Journal of Pharmaceutics·Aikaterini-Theodora ChatzitakiOlga Borges
Feb 26, 2020·ACS Omega·Luke D GeoffrionGrégory Guisbiers

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Methods Mentioned

BETA
infrared spectroscopy
transfection

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