Reactive oxygen species and aldehyde dehydrogenase activity in Hodgkin lymphoma cells

Laboratory Investigation; a Journal of Technical Methods and Pathology
Jun-ichiro IkedaEiichi Morii

Abstract

Tumor cells with tumorigenic potential might be limited to a small population of cells, called cancer-initiating cells (CICs). CICs efficiently form colonies in vitro, yield both CIC and non-CIC populations, maintain reactive oxygen species (ROS) at low levels, show high aldehyde dehydrogenase (ALDH) activity, and are mostly in a quiescent state of the cell cycle. CICs of Hodgkin lymphoma (HL) are small in size, with low levels of ROS. The relationship between ROS level and ALDH activity in CICs was examined in HL cell lines. ROS-low and ALDH-high populations formed colonies in semi-solid cultures more efficiently than ROS-high and ALDH-low populations. ALDH-high populations yielded both ALDH-low and -high populations, whereas ALDH-low populations rarely yielded an ALDH-high population. The number of cells in a quiescent state was significantly greater in ROS-low than in ROS-high cells, whereas that of ALDH-high and ALDH-low cells was comparable to each other. These findings show that ALDH-high and ROS-low cells share CIC-like potential, but they differ in their cell cycle status, suggesting that CICs are comprised of cells with heterogeneous characteristics.

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Citations

Feb 16, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Naoki WadaEiichi Morii
May 23, 2014·International Journal of Radiation Biology·Claudia PeitzschIna Kurth
Dec 2, 2017·International Journal of Molecular Sciences·Marta Prieto-VilaTakahiro Ochiya
Jan 20, 2016·Oncotarget·Hiroyuki TomitaAkira Hara
Dec 3, 2016·Molecular and Clinical Oncology·Jun-Ichiro IkedaEiichi Morii
Nov 6, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Naoki WadaEiichi Morii
Dec 14, 2017·Pathology International·Jun-Ichiro IkedaMasaru Hori
Feb 9, 2019·Stem Cells International·Giuseppe Vassalli
Oct 26, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ying-Hui SongLi Li
Feb 14, 2017·Journal of Toxicologic Pathology·Eiichi Morii
Mar 14, 2020·International Journal of Molecular Sciences·Kehinde Muibat Ibiyeye, Abu Bakar Zakaria Zuki
Apr 17, 2020·Cancers·Vaishnavi MuralikrishnanKenneth P Nephew
Mar 1, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Sahdeo PrasadSanjay K Srivastava

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