Reactive Oxygen Species and Antioxidants in Carcinogenesis and Tumor Therapy.

Biochemistry. Biokhimii︠a︡
S M VostrikovaV G Gogvadze

Abstract

Strictly regulated balance between the formation and utilization of reactive oxygen species (ROS) is the basis of normal functioning of organisms. ROS play an important role in the regulation of many metabolic processes; however, excessive content of ROS leads to the development of various disorders, including oncological diseases, as a result of ROS-induced mutations in DNA. In tumors, high levels of oxygen radicals promote cell proliferation and metastasis. On the other hand, high content of ROS can trigger cell death, a phenomenon used in the antitumor therapy. Water- and lipid-soluble antioxidants, as well as antioxidant enzyme systems, can inhibit ROS generation; however, they should be used with caution. Antioxidants can suppress ROS-dependent cell proliferation and metastasis, but at the same time, they may inhibit the death of tumor cells if the antitumor therapeutic agents stimulate oxidative stress. The data on the role of antioxidants in the death of tumor cells and on the effects of antioxidants taken as dietary supplements during antitumor therapy, are contradictory. This review focuses on the mechanisms by which antioxidants can affect tumor and healthy cells.

References

Jul 1, 1979·Archives of Biochemistry and Biophysics·D R Hunter, R A Haworth
Apr 1, 1994·Free Radical Biology & Medicine·P Ubezio, F Civoli
Dec 22, 1995·The Journal of Biological Chemistry·V J Thannickal, B L Fanburg
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·T M JohnsonT Finkel
Mar 14, 1997·Science·K IraniP J Goldschmidt-Clermont
Apr 10, 1999·Mechanisms of Ageing and Development·K J Lenton, C L Greenstock
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S DelanianJ L Lefaix
Jan 11, 2000·Molecular and Cellular Biology·R EskesJ C Martinou
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Feb 9, 2000·Journal of Bioenergetics and Biomembranes·J Cai, D P Jones
Dec 21, 2000·Japanese Journal of Cancer Research : Gann·O KanbagliM Uysal
Mar 21, 2001·Human Molecular Genetics·J R Nevins
Apr 24, 2001·The American Journal of Gastroenterology·M KennedyA Keshavarzian
Jul 18, 2001·Biological & Pharmaceutical Bulletin·K IsuzugawaY Ogihara
Aug 9, 2001·Antioxidants & Redox Signaling·L W Oberley
Jan 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Martin OttSten Orrenius
Apr 4, 2003·Journal of the American College of Nutrition·Kedar N PrasadWilliam C Cole
Sep 18, 2003·Nature Reviews. Cancer·Gregg L Semenza
Apr 21, 2005·Seminars in Cell & Developmental Biology·Sarah M de JagerJames A H Murray
Apr 28, 2005·Virchows Archiv : an International Journal of Pathology·Xavier DolcetXavier Matias-Guiu
Sep 17, 2005·CA: a Cancer Journal for Clinicians·Gabriella M D'Andrea
Nov 16, 2005·Nature Medicine·Anna A SablinaPeter M Chumakov
May 9, 2006·Biochimica Et Biophysica Acta·Vladimir GogvadzeBoris Zhivotovsky
May 27, 2006·Science·Satoaki MatobaPaul M Hwang
Oct 6, 2006·PLoS Medicine·Anju SinghShyam Biswal
Sep 1, 2007·Integrative Cancer Therapies·Ralph W Moss
Feb 26, 2008·Trends in Cell Biology·Vladimir GogvadzeBoris Zhivotovsky
May 29, 2008·Journal of the National Cancer Institute·Brian D LawendaJeffrey B Blumberg
Aug 22, 2008·PLoS Biology·Cathy Haag-LiautardPeter D Keightley

❮ Previous
Next ❯

Citations

Jul 19, 2021·Free Radical Biology & Medicine·Joyce BagyiDana R Crawford

❮ Previous
Next ❯

Methods Mentioned

BETA
deamination
X-ray

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Biochemical and Molecular Toxicology
Debabrata MajumderDebasish Maiti
Cold Spring Harbor Symposia on Quantitative Biology
Jennifer G GillSean J Morrison
Sub-cellular Biochemistry
Irina MilisavBorut Poljsak
© 2021 Meta ULC. All rights reserved