PMID: 9655527Jul 9, 1998Paper

Reactive oxygen species and DNA oxidation in fetal rat tissues

Free Radical Biology & Medicine
A G FantelR E Person

Abstract

It is well recognized that reactive oxygen species (ROS) are formed during the reperfusion of ischemic tissues and ROS may be pathogenic in adult tissues. Although there is little information on the formation and toxicity of ROS during prenatal life, a strong association has been made between limb and possibly brain malformations and uteroplacental ischemia during fetal stages of gestation. It has been proposed that these malformations result from attack by ROS formed during the resumption of placental perfusion. Studies reported here examined formation of ROS in teratogenically sensitive limb and brain and insensitive heart before and during the period of teratogenic sensitivity. Also examined was the formation of ROS following hypoxia and reoxygenation in fetal culture and DNA hydroxylation in sensitive and insensitive fetal tissues during uteroplacental ischemia and reperfusion in vivo. Rates of formation of superoxide anion radical and hydrogen peroxide declined with increasing gestational age whereas those for hydroxyl radical increased. Hydrogen peroxide generation was greatest in insensitive heart whereas hydroxyl radical formation was significantly lower in brain than in limb or heart, which had comparable rates. Hydrog...Continue Reading

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Citations

Jul 10, 2003·Reproductive Toxicology·Michael F O'HaraThomas B Knudsen
Dec 21, 2000·Free Radical Biology & Medicine·M VianaB Bonet
Dec 16, 2006·Reproduction, Nutrition, Development·Bernard AurousseauDenys Durand
Jul 4, 2007·Journal of Perinatal Medicine·Yaprak Engin-UstünAyşe Kafkasli
Aug 12, 2009·Clinical and Experimental Dermatology·A F KaptanogluK Kilinc
Aug 25, 2004·Clinics in Perinatology·Rivka H Regev, Brian Reichman
Jan 28, 2006·Redox Report : Communications in Free Radical Research·S M ZanataL S Nakao
Jul 13, 2002·Teratology·Alan G Fantel, Richard E Person
Sep 19, 2006·Transplantation Proceedings·S Y HanK C Mun
Jul 28, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Fanneke E AlkemadeMarco C DeRuiter
May 9, 2019·International Journal of Molecular Sciences·Joseph Pierre AboumsallemBart De Geest
Jun 4, 2019·Phytotherapy Research : PTR·Alessandra DurazzoAntonello Santini
Jul 26, 2014·Molecular Medicine Reports·Sameer E Al-HarthiAbdel-Moneim M Osman
Jul 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·David SedmeraEric Raddatz
Aug 31, 2016·Molecular Medicine Reports·Zhiyou CaiGuanghui Chen

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