Reactive oxygen species are second messengers of neurokinin signaling in peripheral sensory neurons.

Proceedings of the National Academy of Sciences of the United States of America
John E LinleyNikita Gamper

Abstract

Substance P (SP) is a prominent neuromodulator, which is produced and released by peripheral damage-sensing (nociceptive) neurons; these neurons also express SP receptors. However, the mechanisms of peripheral SP signaling are poorly understood. We report a signaling pathway of SP in nociceptive neurons: Acting predominantly through NK1 receptors and G(i/o) proteins, SP stimulates increased release of reactive oxygen species from the mitochondrial electron transport chain. Reactive oxygen species, functioning as second messengers, induce oxidative modification and augment M-type potassium channels, thereby suppressing excitability. This signaling cascade requires activation of phospholipase C but is largely uncoupled from the inositol 1,4,5-trisphosphate sensitive Ca(2+) stores. In rats SP causes sensitization of TRPV1 and produces thermal hyperalgesia. However, the lack of coupling between SP signaling and inositol 1,4,5-trisphosphate sensitive Ca(2+) stores, together with the augmenting effect on M channels, renders the SP pathway ineffective to excite nociceptors acutely and produce spontaneous pain. Our study describes a mechanism for neurokinin signaling in sensory neurons and provides evidence that spontaneous pain and hy...Continue Reading

References

Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R LauferZ Selinger
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S De Biasi, A Rustioni
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M M Bosma, B Hille
Jul 1, 1989·Pain·M Nakamura-Craig, T W Smith
Jan 15, 1988·Science·S D MooreG R Siggins
Jun 1, 1983·British Journal of Pharmacology·P R AdamsS W Jones
Mar 28, 1996·European Journal of Pharmacology·T TanabeC Inagaki
Mar 21, 1998·Neuroscience Letters·C BrechenmacherJ L Rodeau
Nov 30, 1999·Trends in Pharmacological Sciences·M Malcangio, N G Bowery
Dec 20, 2000·The Journal of Investigative Dermatology·C WeidnerM Schmelz
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Neil McIntyre
Aug 17, 2002·The Journal of Pharmacology and Experimental Therapeutics·Jennelle Durnett Richardson, Michael R Vasko
Jun 18, 2003·The Journal of General Physiology·Nikita Gamper, Mark S Shapiro
Oct 17, 2003·The Journal of Physiology·Julio F Turrens
Mar 5, 2004·The Journal of Biological Chemistry·Narender R GavvaJames J S Treanor
Aug 12, 2004·The Journal of Biological Chemistry·Yang LiMark S Shapiro
Nov 17, 2004·Regulatory Peptides·Jochen SpringerAxel Fischer
Dec 3, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nikita GamperMark S Shapiro
Oct 10, 2006·The AAPS Journal·Victor J HrubyJosephine Lai
Mar 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qingzhong JiaHailin Zhang
Mar 17, 2007·Experimental Neurology·Adrian Sculptoreanu, William C de Groat
Apr 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert A CrozierMark H Pausch
Nov 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hua ZhangZhi-Qi Zhao
Apr 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cuie QiuMelanie K Tallent
Jul 5, 2008·The European Journal of Neuroscience·Adrian SculptoreanuWilliam C de Groat
Jul 30, 2008·Cell·Wang WangHeping Cheng
Oct 31, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John E LinleyNikita Gamper
Nov 6, 2010·The Journal of Biological Chemistry·Oleg ZaikaMark S Shapiro

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Citations

May 3, 2013·PLoS Neglected Tropical Diseases·Camila GewehrMarcus V Gomez
Jun 28, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Louisa PettingerNikita Gamper
Apr 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lezanne OoiNikita Gamper
Apr 18, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sungjae YooSun Wook Hwang
Sep 18, 2013·Antioxidants & Redox Signaling·Nirakar SahooStefan H Heinemann
Sep 19, 2014·International Journal of Molecular Sciences·Seung-In ChoiSun Wook Hwang
Nov 13, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Claudio BardelliSandra Brunelleschi
Aug 25, 2012·Trends in Cell Biology·Markus SchwarzländerLee J Sweetlove
Sep 19, 2015·Pflügers Archiv : European journal of physiology·Martin SchinkStefan H Heinemann
Jul 6, 2015·The Journal of Pain : Official Journal of the American Pain Society·Lisa A Griffiths, Sarah J L Flatters
Aug 5, 2015·Biochemical and Biophysical Research Communications·Dongyang HuangNikita Gamper
Feb 26, 2014·Autonomic Neuroscience : Basic & Clinical·Valter J Santana-FilhoMark W Chapleau
Apr 22, 2015·Cellular and Molecular Life Sciences : CMLS·Jialie LuoHongzhen Hu
Apr 17, 2014·Antioxidants & Redox Signaling·Nikita Gamper, Lezanne Ooi
Aug 20, 2016·British Journal of Haematology·Amanda M BrandowJulie A Panepinto
Nov 6, 2017·Cellular and Molecular Neurobiology·Toshihide Sato, Yukio Okada
Jan 10, 2018·Frontiers in Cellular Neuroscience·Chen ZhaoHailin Zhang
Aug 12, 2017·British Journal of Pharmacology·Xiaona DuNikita Gamper
Mar 26, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Der-Sheng HanChih-Cheng Chen
Apr 3, 2019·International Journal of Molecular Sciences·Chu-Ting ChangChih-Cheng Chen
Jan 3, 2014·Physiological Reviews·Martin S SteinhoffNigel W Bunnett
Sep 7, 2019·Proceedings of the National Academy of Sciences of the United States of America·Chentao GeCaiyun Fu
Mar 20, 2020·The Journal of Biological Chemistry·Dongyang HuangNikita Gamper
May 30, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tamia K LapointeChristophe Altier
Nov 25, 2020·Archives of Biochemistry and Biophysics·Hiromu ItoHirofumi Matsui

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