Reactive Oxygen Species-Biodegradable Gene Carrier for the Targeting Therapy of Breast Cancer

ACS Applied Materials & Interfaces
Chunhui RuanChen Jiang

Abstract

An ideal gene-carrying vector is supposed to exhibit outstanding gene-condensing capability with positively charged macromolecules to protect the carried gene during in vivo circulation and a rapid dissociation upon microenvironmental stimuli at the aimed sites to release the escorted gene. Currently, it still remains a challenge to develop an ideal gene carrier with efficient transfection ability and low toxicity for clinical applications. Herein, we have innovatively introduced a reactive oxygen species (ROS)-biodegradable boric acid ester linkage in elaborating the design of a gene carrier. In virtue of the featured intracellular characteristics such as the high level of ROS in tumor cells, an ROS-biodegradable electropositive polymer derived from branched polyethylenimine (BPEI) with a low molecular weight (1.2k) through a cross-linking reaction by the boric acid ester bond was developed in this study to achieve condensation and escorting of carried genes. Furthermore, the polymer was modified with substance P (SP) peptide as the targeting ligand through polyethylene glycol. The final fabricated SP-cross-linked BPEI/plasmid DNA nanoparticles exhibit favorable biocompatibility, ROS-cleavability, and fine targeting ability as...Continue Reading

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Citations

Sep 25, 2018·Expert Opinion on Drug Delivery·Simone Hager, Ernst Wagner
Apr 3, 2019·The Journal of Gene Medicine·Jiayan WuXuesi Chen
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Dec 18, 2020·Frontiers in Bioengineering and Biotechnology·Jie LiChangfeng Fu
Jul 8, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Reza MohammadinejadAli Zarrabi
Jul 27, 2021·Advanced Science·Cheng YuJingzhi Ma
Nov 23, 2018·ACS Applied Materials & Interfaces·Jiajia XiangYouqing Shen

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