Reactive oxygen species-dependent Toll/NF-κB activation in the Drosophila hematopoietic niche confers resistance to wasp parasitism

ELife
Isabelle LouradourNathalie Vanzo

Abstract

Hematopoietic stem/progenitor cells in the adult mammalian bone marrow ensure blood cell renewal. Their cellular microenvironment, called 'niche', regulates hematopoiesis both under homeostatic and immune stress conditions. In the Drosophila hematopoietic organ, the lymph gland, the posterior signaling center (PSC) acts as a niche to regulate the hematopoietic response to immune stress such as wasp parasitism. This response relies on the differentiation of lamellocytes, a cryptic cell type, dedicated to pathogen encapsulation and killing. Here, we establish that Toll/NF-κB pathway activation in the PSC in response to wasp parasitism non-cell autonomously induces the lymph gland immune response. Our data further establish a regulatory network where co-activation of Toll/NF-κB and EGFR signaling by ROS levels in the PSC/niche controls lymph gland hematopoiesis under parasitism. Whether a similar regulatory network operates in mammals to control emergency hematopoiesis is an open question.

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Citations

Mar 8, 2019·Genes·Gergely I B VargaViktor Honti
Feb 9, 2019·Genetics·Utpal BanerjeeCarrie M Spratford
Jun 9, 2020·Frontiers in Cell and Developmental Biology·Fangzhou LuoLi Hua Jin
Jun 4, 2019·Frontiers in Physiology·Chami Kim-JoMarylène Poirié
Nov 27, 2019·World Journal of Stem Cells·Holly Matthews, Florian Noulin
Jul 30, 2020·International Journal of Molecular Sciences·Wenwen LanYing Su
Jan 5, 2021·ELife·Manon Destalminil-LetourneauMichele Crozatier
Dec 30, 2020·ELife·Sukanya MadhwalTina Mukherjee
Aug 24, 2021·Frontiers in Cell and Developmental Biology·Sergey A SinenkoAlexey N Tomilin
Jul 11, 2020·Current Biology : CB·Rohan J KhadilkarGuy Tanentzapf

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Methods Mentioned

BETA
transgenic

Software Mentioned

Fiji
GraphPad Prism

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