Reactive oxygen species in the regulation of synaptic plasticity and memory.

Antioxidants & Redox Signaling
Cynthia A Massaad, Eric Klann

Abstract

The brain is a metabolically active organ exhibiting high oxygen consumption and robust production of reactive oxygen species (ROS). The large amounts of ROS are kept in check by an elaborate network of antioxidants, which sometimes fail and lead to neuronal oxidative stress. Thus, ROS are typically categorized as neurotoxic molecules and typically exert their detrimental effects via oxidation of essential macromolecules such as enzymes and cytoskeletal proteins. Most importantly, excessive ROS are associated with decreased performance in cognitive function. However, at physiological concentrations, ROS are involved in functional changes necessary for synaptic plasticity and hence, for normal cognitive function. The fine line of role reversal of ROS from good molecules to bad molecules is far from being fully understood. This review focuses on identifying the multiple sources of ROS in the mammalian nervous system and on presenting evidence for the critical and essential role of ROS in synaptic plasticity and memory. The review also shows that the inability to restrain either age- or pathology-related increases in ROS levels leads to opposite, detrimental effects that are involved in impairments in synaptic plasticity and memor...Continue Reading

References

Feb 1, 1979·Journal of Comparative and Physiological Psychology·C A Barnes
Oct 12, 1992·Neuroscience Letters·C Hölscher, S P Rose
Nov 1, 1992·Journal of Neurochemistry·B Halliwell
Aug 1, 1991·Archives of Biochemistry and Biophysics·R RadiB A Freeman
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C D SmithW R Markesbery
Jan 1, 1991·Free Radical Research Communications·J F TurrensJ M McCord
Oct 1, 1990·Neurology·J Berciano
Jul 1, 1990·Journal of Neurochemistry·D T DexterC D Marsden
Mar 1, 1989·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Y KiyotaA Nagaoka
Nov 1, 1989·Archives of Biochemistry and Biophysics·P Di MascioH Sies
Feb 1, 1989·Journal of Neurochemistry·D T DexterC D Marsden
Nov 15, 1988·Biochemistry·J H Kägi, A Schäffer
Jan 1, 1985·Breast Cancer Research and Treatment·G N HortobagyiG R Blumenschein
Jan 1, 1986·Annual Review of Biochemistry·D H Hamer
Jul 1, 1987·Neurobiology of Aging·M Sarter, A van der Linde
Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R TenhunenR Schmid
Feb 9, 1973·Science·J T RotruckW G Hoekstra
May 1, 1970·The Journal of Clinical Investigation·S A LandawR Schmid
May 11, 1984·Science·G W Burton, K U Ingold
Sep 1, 1981·The American Journal of Clinical Nutrition·K Adam
Jan 1, 1995·Annual Review of Physiology·O W Griffith, D J Stuehr
Jan 1, 1995·Annual Review of Biochemistry·I Fridovich
Aug 1, 1995·Free Radical Biology & Medicine·L PackerH J Tritschler
Sep 1, 1995·The Journal of Experimental Medicine·S H JacksonS M Holland
Sep 1, 1993·Biochemical Pharmacology·C F Zorumski, Y Izumi

❮ Previous
Next ❯

Citations

Aug 21, 2012·Learning & Memory·Aditi Bhattacharya, Eric Klann
Sep 14, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Reno C ReyesRaymond A Swanson
Oct 5, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tao MaEric Klann
May 4, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Timothy DoyleDaniela Salvemini
Dec 20, 2013·International Journal of Molecular Sciences·Jie LiHossein A Ghanbari
Oct 29, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tina I LamRaymond A Swanson
Oct 15, 2013·Molecular Neurobiology·Wanda M SnowBenedict C Albensi
Aug 31, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Na LiGen-Sheng Zhang
Apr 20, 2014·Metabolism: Clinical and Experimental·Wasana PratchayasakulSiriporn C Chattipakorn
Jan 15, 2014·Antioxidants & Redox Signaling·Andrea C Paula-LimaCecilia Hidalgo
Aug 9, 2011·Neurochemical Research·Bárbara TagliariAngela T S Wyse
Jul 25, 2014·Expert Opinion on Therapeutic Targets·Rafael T de SousaHusseini K Manji
Feb 3, 2016·Psychiatry Research·Şeref ŞimşekTuğba Yüksel
Feb 19, 2013·Neuroscience and Biobehavioral Reviews·Eva Morava, Tamás Kozicz
Feb 18, 2016·Neural Plasticity·Freddy Jeanneteau, Margarita Arango-Lievano
Dec 15, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S J MolinaL R Guelman
Feb 1, 2011·Free Radical Biology & Medicine·Daniela SalveminiWilliam L Neumann
Mar 15, 2016·Frontiers in Integrative Neuroscience·Michael Q SteinmanCristina M Alberini
Jan 23, 2016·Oxidative Medicine and Cellular Longevity·Guangyin ZhangJunping Zhang
Jun 17, 2015·Molecular and Cellular Neurosciences·Vidya ChandrasekaranPamela J Lein
Apr 27, 2016·Biological Psychiatry·Byron K Y BitanihirweTsung-Ung W Woo
Mar 21, 2016·Cell Calcium·Kirill Kiselyov, Shmuel Muallem
Mar 28, 2013·Annals of the New York Academy of Sciences·Michael J DevinneyGordon S Mitchell
Oct 21, 2015·Frontiers in Cellular Neuroscience·Carlos Wilson, Christian González-Billault

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
deamination

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jarin HongpaisanS Brian Andrews
Nature Reviews. Molecular Cell Biology
Douglas T HessJonathan S Stamler
Annual Review of Cell and Developmental Biology
S R Jaffrey, S H Snyder
© 2021 Meta ULC. All rights reserved