Reactive oxygen species mediate visceral pain-related amygdala plasticity and behaviors

Pain
Guangchen JiVolker Neugebauer

Abstract

Accumulating evidence suggests an important contribution of reactive oxygen species (ROS) to pain and neuropsychiatric disorders, but their role in pain-related plasticity in the brain is largely unknown. Neuroplasticity in the central nucleus of the amygdala (CeA) correlates positively with pain behaviors in different models. Little is known, however, about mechanisms of visceral pain-related amygdala changes. The electrophysiological and behavioral studies reported here addressed the role of ROS in the CeA in a visceral pain model induced by intracolonic zymosan. Vocalizations to colorectal distension and anxiety-like behavior increased after intracolonic zymosan and were inhibited by intra-CeA application of a ROS scavenger (tempol, a superoxide dismutase mimetic). Tempol also induced a place preference in zymosan-treated rats but not in controls. Single-unit recordings of CeA neurons in anesthetized rats showed increases of background activity and responses to visceral stimuli after intracolonic zymosan. Intra-CeA application of tempol inhibited the increased activity but had no effect under normal conditions. Whole-cell patch-clamp recordings of CeA neurons in brain slices from zymosan-treated rats showed that tempol decre...Continue Reading

References

Nov 17, 1994·Annals of the New York Academy of Sciences·T C PellmarL S Myers
Oct 12, 2000·Cellular and Molecular Life Sciences : CMLS·P Maher, D Schubert
Feb 22, 2002·Experimental Physiology·Caroline Gauriau, Jean-François Bernard
Apr 3, 2002·The American Journal of Gastroenterology·B BonazC Segebarth
Jun 14, 2003·Gastroenterology·Bruce D NaliboffEmeran A Mayer
Dec 4, 2003·The Journal of Comparative Neurology·Caroline Gauriau, Jean-François Bernard
May 12, 2004·Neuroscience Letters·Jeong Seok Han, Volker Neugebauer
May 25, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Volker NeugebauerJeong S Han
Oct 9, 2004·Molecular Interventions·Jin Mo Chung
Jun 25, 2005·The Journal of Comparative Neurology·Arpád DobolyiMiklós Palkovits
Jan 20, 2006·The FEBS Journal·Christos Chinopoulos, Vera Adam-Vizi
Mar 10, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Brent Myers, Beverley Greenwood-Van Meerveld
Mar 30, 2007·Molecular Pain·Volker NeugebauerGuangchen Ji
Mar 30, 2007·Arthritis and Rheumatism·B KulkarniA K P Jones
Apr 2, 2008·Antioxidants & Redox Signaling·Cecilia Hidalgo, Paulina Donoso
Apr 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yu Fu, Volker Neugebauer
May 6, 2008·The Journal of Pharmacology and Experimental Therapeutics·Anbrin MasoodJames M O'Donnell
Jun 25, 2008·Molecular Pain·Yarimar Carrasquillo, Robert W Gereau
Jan 9, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Erica S SchwartzKyungsoon Chung
Jan 24, 2009·Brain Research Reviews·Volker NeugebauerSean C Mackey
Jul 25, 2009·Journal of Neurophysiology·Guangchen Ji, Volker Neugebauer
Sep 29, 2009·Nature Neuroscience·Tamara KingFrank Porreca
Oct 2, 2009·Neuroreport·Hee Young KimKyungsoon Chung
Nov 13, 2009·Journal of Neurophysiology·Kwan Yeop LeeJin Mo Chung

❮ Previous
Next ❯

Citations

Sep 15, 2016·Journal of Experimental Neuroscience·Thiago Fernando BeckhauserRoberto De Pasquale
Jun 2, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Taína ScheidWania Aparecida Partata
Oct 9, 2020·Cellular and Molecular Neurobiology·Olga A LyubashinaSergey S Panteleev
Oct 8, 2020·Animal Models and Experimental Medicine·Bharata Regmi, Manoj K Shah
Jan 24, 2021·Archives of Medical Research·Rosa Ventura-MartinezFrancisco Javier López-Muñoz
Apr 1, 2021·Free Radical Biology & Medicine·Gesine WackWiebke Kallenborn-Gerhardt
Mar 29, 2021·Neuroscience Letters·Iryna A KhasabovaDonald A Simone
Apr 10, 2018·ACS Chemical Neuroscience·Takaki Kiritoshi, Volker Neugebauer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.