Reactive oxygen species-mediated mitochondria-to-nucleus signaling: a key to aging and radical-caused diseases

Science's STKE : Signal Transduction Knowledge Environment
Peter Storz

Abstract

Mitochondria-generated reactive oxygen species have been implicated as a common feature that connects aging of organisms and age-related diseases. Efficient elimination of these radicals by antioxidants correlates with increased life span. Understanding how the mitochondrion signals to the nucleus to regulate antioxidant proteins might be a key to aging processes and treatment of human diseases.

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Citations

Sep 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Juliano L SartorettoThomas Michel
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