Dec 5, 2019

Reactive oxygen species metabolism-based prediction model and drug for patients with recurrent glioblastoma

Aging
Nian TanWei Zhao

Abstract

Tumor recurrence is the main cause of poor prognosis of GBM. Finding the characteristics of recurrent GBM that provide early warning of tumor recurrence can provide guidance for the clinical treatment of recurrent GBM. Reactive oxygen species (ROS) biosynthetic processes was significantly elevated in recurrent GBM. The recurrent risk score based on the ROS biosynthetic process was closely related to tumor purity and tumor immune functions. The quantitative risk assessment system could be used to predict the recurrence time of GBM. Gallic acid, a compound with high anti-oxidation activity and low cytotoxicity, was screened as a potential chemotherapy sensitizer for recurrent GBM. The quantitative risk assessment system based on ROS biosynthetic process could be used for early warning of GBM recurrence. Combination of low-dose gallic acid and temozolomide could improve therapeutic outcomes in recurrent GBM. A total of 663 primary and recurrent GBM samples with clinical and microarray data were included in this study. GSVA, LASSO-COX, and Kaplan-Meier survive curve were performed to construct and verify a quantitative risk assessment system for GBM recurrence prediction. An antioxidant capacity test and cell viability test were us...Continue Reading

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Study
Cyclooxygenase 2
Tumor Immunity
Advice
Antioxidant Effect
Antioxidants
Neoplasms
Recurrent Tumor
Allergens
Administration of Antineoplastic Agent

Related Feeds

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Aging Genetics

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Related Papers

Epigenetics : Official Journal of the DNA Methylation Society
Jennifer ClarkeNagi G Ayad
Zhonghua wai ke za zhi [Chinese journal of surgery]
H H Jiang, S Lin
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Hee-Young JeonHyunggee Kim
© 2020 Meta ULC. All rights reserved