Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia.

American Journal of Respiratory and Critical Care Medicine
Helen M MarriottD H Dockrell

Abstract

The role of NADPH oxidase activation in pneumonia is complex because reactive oxygen species contribute to both microbial killing and regulation of the acute pulmonary infiltrate. The relative importance of each role remains poorly defined in community-acquired pneumonia. We evaluated the contribution of NADPH oxidase-derived reactive oxygen species to the pathogenesis of pneumococcal pneumonia, addressing both the contribution to microbial killing and regulation of the inflammatory response. Mice deficient in the gp91(phox) component of the phagocyte NADPH oxidase were studied after pneumococcal challenge. gp91(phox)(-/-) mice demonstrated no defect in microbial clearance as compared with wild-type C57BL/6 mice. A significant increase in bacterial clearance from the lungs of gp91(phox)(-/-) mice was associated with increased numbers of neutrophils in the lung, lower rates of neutrophil apoptosis, and enhanced activation. Marked alterations in pulmonary cytokine/chemokine expression were also noted in the lungs of gp91(phox)(-/-) mice, characterized by elevated levels of tumor necrosis factor-alpha, KC, macrophage inflammatory protein-2, monocyte chemotactic protein-1, and IL-6. The greater numbers of neutrophils in gp91(phox)(...Continue Reading

References

Jan 1, 1979·The Journal of Experimental Medicine·H Rosen, S J Klebanoff
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·U H von AndrianE C Butcher
May 11, 1991·Reviews of Infectious Diseases·R B Johnston
Jan 1, 1974·Infection and Immunity·J Pitt, H P Bernheimer
Dec 1, 1974·Infection and Immunity·S B ShohetD G Poplack
Oct 1, 1994·The Biochemical Journal·C Boudier, J G Bieth
Nov 1, 1994·American Journal of Respiratory and Critical Care Medicine·W WangT A Raffin
Apr 1, 1996·Journal of Leukocyte Biology·D G Remick, L Villarete
Feb 1, 1996·Molecular Microbiology·B SpellerbergH R Masure
Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·A TorresJ Serra
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·G Matute-BelloT R Martin
Apr 9, 1998·International Immunology·Y KasaharaN Taniguchi
Mar 24, 1999·Journal of Leukocyte Biology·H Lundqvist-Gustafsson, T Bengtsson
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·C Haslett
Nov 26, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·U BankS Ansorge
Feb 26, 2000·Infection and Immunity·A M CooperI M Orme
May 4, 2000·The New England Journal of Medicine·L B Ware, M A Matthay
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·K KawabataH Ohno
Nov 15, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·E AbrahamJ Arcaroli
Dec 7, 2000·The New England Journal of Medicine·J A Lekstrom-Himes, J I Gallin
Feb 24, 2001·Ryōikibetsu shōkōgun shirīzu·M Iwata, H Nunoi
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·I FillionM G Bergeron
Oct 25, 2001·Archives of Biochemistry and Biophysics·S BhattacharjeeJ W Heinecke
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiao-pei GaoAsrar B Malik
Jul 16, 2002·Infection and Immunity·Erjian WangMichel G Bergeron
Dec 10, 2002·American Journal of Respiratory and Critical Care Medicine·Henry Jay Forman, Martine Torres
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·David H DockrellMoira K B Whyte
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ruxana T SadikotJohn W Christman
Sep 21, 2004·Nature Reviews. Microbiology·Ferric C Fang
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bing RenAlexander J Szalai
Jul 19, 2005·Nature Medicine·Jose A CancelasDavid A Williams
Oct 6, 2005·Journal of Leukocyte Biology·Forest R SheppardChristopher C Silliman
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew R JonesJoseph P Mizgerd
Jan 3, 2006·The Journal of Infectious Diseases·Matthew R JonesJoseph P Mizgerd
Apr 14, 2006·The European Respiratory Journal·M I RestrepoA Anzueto

❮ Previous
Next ❯

Citations

Nov 28, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D ViasusJ Carratalà
Apr 3, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·B A Evans, D E Rozen
Dec 5, 2009·Acta Pharmacologica Sinica·Qing-shan LiuGuan-hua Du
Apr 9, 2011·Molecular & Cellular Proteomics : MCP·Martin A BewleyDavid H Dockrell
Apr 1, 2009·Antioxidants & Redox Signaling·Brian GriffithVictor J Thannickal
May 2, 2012·Infection and Immunity·Balamayooran TheivanthiranSamithamby Jeyaseelan
Aug 4, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Stephen P KantrowSteve Nelson
Oct 24, 2012·Journal of Leukocyte Biology·Jinlong JianChuanju Liu
May 17, 2011·Annals of Thoracic Medicine·Feisal A Al-Kassimi, Muhammad A Chishi
Sep 3, 2013·Antioxidants & Redox Signaling·Claudia N Paiva, Marcelo T Bozza
Oct 8, 2013·Antioxidants & Redox Signaling·Karen BernardVictor J Thannickal
May 30, 2008·Seminars in Immunopathology·Michela G SchäppiKarl-Heinz Krause
May 30, 2008·Seminars in Immunopathology·J David LambethRobert A Clark
Aug 11, 2007·American Journal of Respiratory Cell and Molecular Biology·Katharina TautUlrich A Maus
May 17, 2008·American Journal of Respiratory Cell and Molecular Biology·Feng XuKlaus Dalhoff
Aug 9, 2012·Chest·David H DockrellTimothy J Mitchell
Sep 29, 2011·Particle and Fibre Toxicology·Jong Sung KimPeter S Thorne
Jan 30, 2007·Respiratory Research·María Del Mar García-SuárezFrancisco J Méndez
Apr 17, 2015·PLoS Pathogens·Kipyegon KiturAlice Prince
Oct 14, 2016·American Journal of Respiratory and Critical Care Medicine·Hajera AmatullahUNKNOWN Canadian Critical Care Translational Biology Group
Apr 30, 2013·International Journal of Molecular Sciences·Frank A D T G WagenerDitte M S Lundvig
Jan 13, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Siyao ChenHongfang Jin
Jan 23, 2019·Journal of Leukocyte Biology·Sankar BaruahJulia Klesney-Tait
Sep 6, 2014·Journal of Applied Physiology·Clarice R OlivoMilton A Martins
Feb 15, 2019·Particle and Fibre Toxicology·Stephen J EvansShareen H Doak
Jul 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alistair J Standish, Jeffrey N Weiser
Mar 2, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sanjay BatraSamithamby Jeyaseelan
Feb 25, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keer Sun, Dennis W Metzger
May 19, 2017·Frontiers in Cellular and Infection Microbiology·Elsa N Bou GhanemAlexander Panda
Mar 2, 2019·International Journal of Environmental Research and Public Health·Kuan-Jen BaiHsiao-Chi Chuang
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marina Gomes MachadoLirlândia Pires Sousa

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.