Reactive oxygen species scavenger N-acetyl cysteine reduces methamphetamine-induced hyperthermia without affecting motor activity in mice

Temperature : Multidisciplinary Biomedical Journal
Manuel Sanchez-AlavezMaria Cecilia Garibaldi Marcondes

Abstract

Hyperthermia is a potentially lethal side effect of Methamphetamine (Meth) abuse, which involves the participation of peripheral thermogenic sites such as the Brown Adipose Tissue (BAT). In a previous study we found that the anti-oxidant N-acetyl cysteine (NAC) can prevent the high increase in temperature in a mouse model of Meth-hyperthermia. Here, we have further explored the ability of NAC to modulate Meth-induced hyperthermia in correlation with changes in BAT. We found that NAC treatment in controls causes hypothermia, and, when administered prior or upon the onset of Meth-induced hyperthermia, can ameliorate the temperature increase and preserve mitochondrial numbers and integrity, without affecting locomotor activity. This was different from Dantrolene, which decreased motor activity without affecting temperature. The effects of NAC were seen in spite of its inability to recover the decrease of mitochondrial superoxide induced in BAT by Meth. In addition, NAC did not prevent the Meth-induced decrease of BAT glutathione. Treatment with S-adenosyl-L-methionine, which improves glutathione activity, had an effect in ameliorating Meth-induced hyperthermia, but also modulated motor activity. This suggests a role for the remain...Continue Reading

References

Feb 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G P BrayR Williams
Jan 1, 1984·Pharmacology & Therapeutics·W G Clark, J M Lipton
Jul 1, 1994·Annals of Emergency Medicine·C W Callaway, R F Clark
Feb 1, 1994·Journal of Leukocyte Biology·W O CarterJ P Robinson
Jan 1, 1995·Methods in Enzymology·M ReersL B Chen
Jul 25, 2000·British Journal of Pharmacology·S CuzzocreaA P Caputi
Aug 30, 2000·Cardiovascular Research·S CuzzocreaA P Caputi
Feb 8, 2002·Journal of Addictive Diseases·Sara L SimonWalter Ling
Apr 12, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Johannes KleinC Ronald Kahn
Apr 1, 2003·Der Anaesthesist·M U GerbershagenF Wappler
Jul 9, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·P David AdelsonUNKNOWN World Federation of Pediatric Intensive and Critical Care Societies
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
Apr 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Takahiro ShimizuYasunobu Okada
Jul 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul M ThompsonEdythe D London
Sep 4, 2004·Biochemical Pharmacology·Jon E SpragueEdward Mills
Jul 28, 2005·British Journal of Sports Medicine·J E Smith
Feb 28, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Derick HanNeil Kaplowitz
Apr 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Trinitat CambrasHoracio O de la Iglesia
Aug 4, 2007·European Journal of Pharmacology·Yohtaro NumachiIchiro Sora
Sep 14, 2007·The Cerebellum·Motoki Arakawa, Yoshihisa Ito
Jun 3, 2008·Methods in Molecular Biology·Barbara Cannon, Jan Nedergaard
Aug 6, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Servio H RamirezYuri Persidsky
Jul 30, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Raghava PotulaYuri Persidsky
Oct 12, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Chengbin XueHuibi Xu
Oct 13, 2010·The Journal of Biological Chemistry·Jerome GarciaEnrique Cadenas
Dec 7, 2010·Current Opinion in Chemical Biology·Edward T ChouchaniMichael P Murphy
Dec 29, 2010·Cell Research·Michael J Morgan, Zheng-gang Liu
Jan 5, 2011·The Journal of Biological Chemistry·Steven R DanielsonJulie K Andersen
Apr 2, 2011·The Journal of Biological Chemistry·Saori R YoshiiNoboru Mizushima
Sep 14, 2011·Oxidative Medicine and Cellular Longevity·Igor Afanas'ev
Sep 24, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ryan J MaillouxMary-Ellen Harper
Feb 23, 2012·Current Pharmaceutical Biotechnology·Kennon Heard, Jody Green
Sep 27, 2012·American Journal of Therapeutics·Shawn M VarneyKennon Heard

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Citations

Apr 19, 2016·Journal of Drug and Alcohol Research·Yuko Yasui, Tsung-Ping Su
Feb 3, 2016·Temperature : Multidisciplinary Biomedical Journal·Nikki BortellMaria Cecilia Garibaldi Marcondes
Sep 26, 2017·Temperature : Multidisciplinary Biomedical Journal·Alexandre A Steiner
Nov 12, 2015·Frontiers in Microbiology·Sonia MediouniSusana T Valente
Aug 27, 2017·The Journal of Biological Chemistry·Edward T ChouchaniBruce M Spiegelman
Oct 5, 2016·MedChemComm·Zhiqiang WuZhenqiang Wu
Nov 14, 2019·Neural Regeneration Research·Li-Min GuoKun Xiong
Feb 26, 2020·International Journal of Molecular Sciences·Sylwia WrotekArtur Dzialuk
Jan 1, 2015·Temperature : Multidisciplinary Biomedical Journal·Félix CarvalhoAndrej A Romanovsky
Dec 15, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Manuel Sanchez-AlavezMaria Cecilia Garibaldi Marcondes

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Methods Mentioned

BETA
PCR
confocal microscopy

Software Mentioned

Genescript
Zen Microscope
ImageJ
PCR Array Data Analysis Software
Prism
PrimerExpress

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