Reactive oxygen species-sensitive nanophotosensitizers of aminophenyl boronic acid pinacol ester conjugated chitosan-g-methoxy poly(ethylene glycol) copolymer for photodynamic treatment of cancer.

Biomedical Materials
Young-Il JeongJae Woong Koh

Abstract

The aim of this study is to prepare reactive oxygen species (ROS)-sensitive nanophotosensitizers for targeted delivery of chlorin e6 (Ce6) and photodynamic tumor therapy. For this purpose, thiodipropionic acid (TDPA) was conjugated with phenyl boronic acid pinacol ester (PBAP) (TDPA-PBAP conjugates) and then the TDPA-PBAP conjugates were attached to the chitosan backbone of chitosan-g-methoxy poly(ethylene glycol) (ChitoPEG) copolymer (ChitoPEG-PBAP). Ce6-incorporated ChitoPEG-PBAP nanophotosensitizers have an ROS-sensitive manner in vitro. The size of ChitoPEG-PBAP nanoparticles increased or disintegrated in a responsive manner against H2O2 concentration. The Ce6 release rate from ChitoPEG-PBAP nanophotosensitizers also increased by adding H2O2. These results indicated that nanophotosensitizers have sensitivity against ROS and showed triggered Ce6 release behavior. ChitoPEG-PBAP nanophotosensitizers can be more efficiently internalized into cancer cells compared to Ce6 alone and then produce ROS in a more efficient manner. Furthermore, ChitoPEG-PBAP nanophotosensitizers suppressed the viability of cancer cells in vitro and tumor growth in vivo with higher efficacy compared to Ce6 alone. Furthermore, ChitoPEG-PBAP nanophotosens...Continue Reading

References

Apr 1, 1996·European Journal of Oral Sciences·J M NautaA Vermey
May 2, 2003·Nature Reviews. Cancer·Dennis E J G J DolmansRakesh K Jain
Sep 27, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Harubumi KatoHirohisa Horinouchi
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ruth A KleinermanJoseph F Fraumeni
May 30, 2009·Nature Reviews. Drug Discovery·Dunyaporn TrachoothamPeng Huang
Jan 14, 2010·Journal of Cancer Research and Clinical Oncology·M WakuiH Mizunuma
Nov 30, 2010·Photodiagnosis and Photodynamic Therapy·Isabelle AertsMarie France Poupon
May 28, 2011·CA: a Cancer Journal for Clinicians·Patrizia AgostinisJakub Golab
Aug 5, 2011·Drugs·Alberto J Montero, Jacek Jassem
Jul 10, 2013·International Journal of Pharmaceutics·Hye Myeong LeeDae Hwan Kang
Jan 11, 2014·Seminars in Cancer Biology·Ana CostaFatima Mechta-Grigoriou
Feb 12, 2014·Antioxidants & Redox Signaling·Valery V Khramtsov, Robert J Gillies
Oct 4, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhigui SuCan Zhang
Oct 31, 2015·International Journal of Molecular Sciences·Silvia Rocío LucenaYolanda Gilaberte
Dec 3, 2015·Cellular and Molecular Life Sciences : CMLS·Valéry L PayenPierre Sonveaux
Dec 29, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Kar Perng LowKhee Chee Soo
Feb 5, 2016·Cancer Letters·Ting Wu, Yun Dai
Nov 5, 2016·Free Radical Research·Boyun Kim, Yong Sang Song
Jun 13, 2017·Current Opinion in Cell Biology·Miguel Reina-CamposMaria Diaz-Meco
Dec 12, 2017·Journal of Cellular Biochemistry·Flávia Cristina P RosinLuciana Corrêa
Oct 26, 2018·Advances in Experimental Medicine and Biology·S V Berwin SinghGilson Khang
Sep 10, 2019·International Journal of Nanomedicine·Abhilash D PandyaGunhild M Mælandsmo
Dec 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hongzhang DengAnjie Dong

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.