PMID: 8959899Jul 1, 1996Paper

Reactive perforating collagenosis--transepidermal elimination of type IV collagen

Clinical and Experimental Dermatology
T HerzingerP Kind

Abstract

Reactive perforating collagenosis (RPC) is a rare skin disorder characterized by reddish papules with a central keratotic plug which appear mainly on the extensor aspects of the limbs. An idiopathic or classical variant has been delineated from an acquired one which occurs in diabetes mellitus and renal failure. Histopathological examination of the lesions shows transepidermal elimination of abnormally staining bundles of collagen. To clarify the origin of this collagenous material we performed an immunohistochemical study including biopsies of two patients with RPC, one classical and one acquired. Staining reactivity to antibodies against type IV collagen was observed, thus providing evidence that the collagen eliminated in RPC may be derived from the basement membrane zone.

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Citations

Jul 7, 2011·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·N ScolaA Kreuter
Aug 3, 2005·American Journal of Clinical Dermatology·Binh T NgoMarc S Rendell
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Feb 24, 2009·Journal of the American Academy of Dermatology·Thilo GambichlerAlexander Kreuter
Jun 15, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·V RameshR Makkar
May 31, 2013·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Gunnar Wagner, Michael Max Sachse
Jul 16, 2010·The Journal of Dermatology·Anthony KarpouzisConstantin Kouskoukis
Mar 30, 2013·Anais Brasileiros De Dermatologia·Hemma TilzCesare Massone
Jul 17, 2001·The British Journal of Dermatology·K QueringsD Bachter
Oct 12, 2010·International Journal of Dermatology·Enas A S AttiaNagwa M Youssef
Mar 16, 2006·The British Journal of Dermatology·S R HoqueC A Holden
May 10, 2006·Clinical and Experimental Dermatology·G Martín-EzquerraP Umbert-Millet
Aug 9, 2001·Journal of Cutaneous Pathology·T OchiaiA Takayama
Jul 15, 2021·European Journal of Medical Research·Binrong YeYeqiang Liu

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