Reactive perforating collagenosis: a condition that may be underdiagnosed

The Australasian Journal of Dermatology
A C SatchellS Lee

Abstract

Reactive perforating collagenosis is a perforating disorder developing in adults, usually in association with diabetes mellitus or renal failure. We present three cases diagnosed at the Royal Prince Alfred Hospital in a 5 month period. All three patients had long-standing diabetes mellitus, hypertension, hypercholesterolaemia and ischaemic heart disease. Each patient presented with generalized pruritus and a papular eruption across the trunk and limbs. More than one biopsy or multiple levels were needed before the diagnostic histological features were seen. The first patient responded to 0.5% phenol with 10% glycerine in sorbolene cream. The second patient did not respond to topical betamethasone diproprionate 0.5 mg/g cream and antihistamines (hydroxyzine 25 mg nocte) and required narrow-band ultraviolet (UV) B. The third patient, having failed to respond to topical betamethasone diproprionate 0.5 mg/g cream and wet dressings, antihistamines (hydroxyzine 25 mg tds and doxepin 50 mg nocte) and UVB required acitretin 25 mg orally per day. Because reactive perforating collagenosis responds to treatment, we believe this condition should be considered in patients with diabetes mellitus or renal failure presenting with pruritus and ...Continue Reading

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Citations

Mar 3, 2009·Seminars in Dialysis·Katharine B CordovaLeslie Robinson-Bostom
Sep 13, 2006·Journal of Biomedical Optics·Basil M HantashKin Foong Chan
Aug 25, 2004·Journal of the European Academy of Dermatology and Venereology : JEADV·T BrinkmeierP J Frosch
Aug 31, 2007·The Journal of Dermatology·Eun Jung KimYoung Min Park
Jul 16, 2010·The Journal of Dermatology·Anthony KarpouzisConstantin Kouskoukis
Feb 5, 2005·Journal of the American Academy of Dermatology·Thilo GambichlerAlexander Kreuter
Jun 22, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Judit LukácsPeter Elsner
Jul 11, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Judit LukácsPeter Elsner
Oct 12, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Timur A GalperinKieron S Leslie
Jun 22, 2017·The Australasian Journal of Dermatology·Jeremy ReidMohammed Al Abadie

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