Reactive radical scavenging and xanthine oxidase inhibition of proanthocyanidins from Carallia brachiata

Phytotherapy Research : PTR
Preecha PhuwapraisirisanSanti Tip-Pyang

Abstract

Antioxidant-guided separation of Carallia brachiata bark led to a new A-type trimeric proanthocyanidin named carallidin (1), along with mahuannin A (2) and p-hydroxy benzoic acid (3). The structure of 1 was fully characterized by interpretation of spectroscopic data and chemical means. Compounds 1 and 2 exhibited radical scavenging against DPPH (IC(50) 102 and 182 microm) and superoxide radical (IC(50) 1.47 and 9.74 microm). In addition, 1 and 2 also inhibited xanthine oxidase with IC(50) values of 12.9 and 16.0 microm.

References

Nov 1, 1983·Chemical & Pharmaceutical Bulletin·T NoroS Fukushima
Jun 1, 2001·Chemical & Pharmaceutical Bulletin·K KamiyaT Satake
Oct 13, 2004·Phytotherapy Research : PTR·Nathathai WiboonpunSanti Tip-pyang
Nov 30, 2004·Fitoterapia·S-K LingI Kouno

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Citations

May 27, 2010·Indian Journal of Pharmaceutical Sciences·B KrishnaveniB Madhava Reddy
Apr 25, 2008·Life Sciences·José J LópezJuan A Rosado
Jan 22, 2014·Natural Product Research·Guiquan JiangGuizhen Fang
May 13, 2006·Phytotherapy Research : PTR·Preecha PhuwapraisirisanSanti Tip-Pyang
Nov 8, 2018·Chemical Biology & Drug Design·Arshad MehmoodChengtao Wang
Dec 18, 2007·Molecular Nutrition & Food Research·Patricia M Aron, James A Kennedy
Jan 26, 2010·Expert Opinion on Drug Metabolism & Toxicology·Mohammad-Reza Rashidi, Hossein Nazemiyeh

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