PMID: 7544536Aug 1, 1995Paper

Reactive species in ischemic rat lung injury: contribution of peroxynitrite

The American Journal of Physiology
H IschiropoulosA B Fisher

Abstract

Lung ischemia-reperfusion represents a potentially important mechanism for diverse forms of tissue injury associated with decreased pulmonary flow. Previous studies demonstrated oxidative injury in ischemic-reperfused lungs. The present study was designed to evaluate the contribution of nitric oxide and peroxynitrite in tissue injury. The levels of the stable decomposition products of nitric oxide and peroxynitrite, nitrite plus nitrate, were twofold greater than control during reperfusion after 60 min of ischemia. Inhibition of nitric oxide synthesis by endotracheal insufflation of 5 mM NG-nitro-L-arginine methyl ester, 30 min before the induction of ischemia, decreased the production of lung thiobarbituric acid reactive substances (TBARS) by 67% (P < 0.05, n = 5), TBARS released into the lung perfusate by 55% (P < 0.05, n = 5), lung-conjugated dienes by 61% (P < 0.05, n = 5), and dinitrophenylhydrazine-reactive protein carbonyl levels by 86% (P < 0.05, n = 5). Amino acid analysis of tissue homogenates from lungs exposed to 60 min of ischemia and 60 min of reperfusion revealed a 1.8-fold (P < 0.05, n = 5) increase in nitrotyrosine concentration compared with 2 h continuously perfused lungs. Inhibition of nitric oxide synthesis...Continue Reading

Citations

May 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·A BananA Keshavarzian
Sep 12, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·A BananA Keshavarzian
Oct 28, 2003·Journal of Neurotrauma·Douglas S DeWitt, Donald S Prough
Jan 13, 2004·Journal of Applied Physiology·B D NossamanP J Kadowitz
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A K BrzezinskaS J Elliott
Oct 23, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Z WeiA B Fisher
Mar 9, 2007·American Journal of Physiology. Renal Physiology·Jose Luis ViñasAnna Sola
Oct 29, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·M A MoxleyJ A Corbett
Jan 31, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jae W LeeJorge A Gutierrez
Nov 15, 2011·Annual Review of Physiology·Elizabeth A BrowningAron B Fisher
Mar 6, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Russell P BowlerJames D Crapo
Jun 30, 2004·The Annals of Thoracic Surgery·Hideki YamashitaTadayuki Oka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Respiratory Cell and Molecular Biology
G ZhaoA B Fisher
Clinica Chimica Acta; International Journal of Clinical Chemistry
T Koken, M Inal
American Journal of Respiratory and Critical Care Medicine
H IschiropoulosS R Thom
© 2021 Meta ULC. All rights reserved