Reactive thrombocytosis in acute infectious diseases: Prevalence, characteristics and timing

European Journal of Internal Medicine
Ami SchattnerIna Dubin

Abstract

Reactive thrombocytosis is known to occur in infectious, inflammatory and neoplastic diseases. However, the characteristics of its association with acute infections (ID) has not been systematically studied. A department of internal medicine in a general teaching hospital. Retrospective chart review of admitted patients with a confirmed diagnosis of community-acquired pneumonia (CAP), urinary tract infection (UTI) or skin and soft tissue infection (SSTI). Key clinical and laboratory data were retrieved and patients with platelet counts >400 × 109/L who had no alternative cause of thrombocytosis were studied longitudinally and compared to patients with acute infections who had no thrombocytosis. Thirty two of 421 patients with acute infections (ID) had infection-associated thrombocytosis (7.6%): 11/125 patients with CAP (8.8%), 13/205 patients with UTI (6.3%) and 8/91 (8.8%) patients with SSTI. Their median ages (77-78 years), gender (48% males), admission temperature, Hb, and WBC were not significantly different from ID patients without thrombocytosis. However, patients with thrombocytosis had longer hospital stays (P = 0.001), more bacteremias (P = 0.048) and in 4/32 (12/5% vs. 2%) significantly increased combined mortality or ...Continue Reading

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