DOI: 10.1101/490086Dec 8, 2018Paper

Reactive/proactive aggression specific cortical and subcortical alterations in children and adolescents with disruptive behavior

BioRxiv : the Preprint Server for Biology
Jilly NaaijenJan K Buitelaar

Abstract

Objective: Maladaptive aggression, as present in conduct disorder (CD) and, to a lesser extent, oppositional defiant disorder (ODD), has been associated with structural alterations in various brain regions, such as ventromedial prefrontal cortex (vmPFC), anterior cingulate cortex (ACC), amygdala, insula and ventral striatum. Although aggression can be subdivided into reactive and proactive subtypes, no neuroimaging studies have yet investigated if any structural brain alterations are associated with either of the subtypes specifically. Here we investigated this association in predefined regions of interest. Method: T1-weighted magnetic resonance images were acquired from 158 children and adolescents with aggressive behavior (ODD/CD) and 96 controls in a multi-centre study. Aggression subtypes were assessed by questionnaires. Cortical volume and subcortical volumes and shape were determined using Freesurfer and the FMRIB integrated registration and segmentation tool. Associations between volumes and continuous measures of aggression were established using multilevel linear mixed effects models. Results: In cases only proactive aggression was negatively associated with amygdala volume (b=-11.82, p=0.05), while reactive aggression...Continue Reading

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