PMID: 11914447Mar 27, 2002Paper

Reactivity and vulnerability to stress-associated risk for upper respiratory illness

Psychosomatic Medicine
Sheldon CohenStephen B Manuck

Abstract

We tested the hypothesis that the greater a person's laboratory stress-elicited elevation in cortisol, the greater the life stress-related risk for upper respiratory infection (URI). We also tested the prediction that the greater the laboratory stress-elicited rise in natural killer cell (NK) cytotoxicity, the smaller the life stress-related URI risk. Finally, we explored whether sympathetic nervous system (SNS) and enumerative immune reactivities to laboratory stress moderate the relation between life stress and URI. At baseline, 115 healthy subjects were administered a negative stressful life events checklist and were tested to assess their SNS (blood pressure, heart rate, and catecholamines), HPA (cortisol), and immune (NK cell cytotoxicity and lymphocyte subsets) reactivities to laboratory speech tasks administered 2 weeks apart. Responses were averaged across the two laboratory assessments to create reactivity scores. After these assessments were completed, participants were followed weekly for 12 consecutive weeks. At each follow-up they completed a measure of perceived stress experienced over the last week. They were also instructed to contact the study coordinator if they had a cold or flu at any time during follow-up. ...Continue Reading

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Citations

Jun 3, 2005·Neuropsychology Review·Leonard A JasonCaroline King
Jul 16, 2005·Stress : the International Journal on the Biology of Stress·Julie M Turner-Cobb
Jan 10, 2012·Journal of Behavioral Medicine·Thomas F DensonIsabelle Granville-Smith
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Apr 12, 2013·Psychosomatic Medicine·J David CreswellMaureen Satyshur
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Apr 13, 2021·Brain, Behavior, & Immunity Health·Thomas RitzAnnie T Ginty
Mar 7, 2020·Brain, Behavior, & Immunity Health·Ryan L BrownChristopher P Fagundes

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