Reactivity in the human retinal microvasculature measured during acute gas breathing provocations

Scientific Reports
Angelina DuanBang V Bui

Abstract

Although changes in vessel diameter following gas perturbation have been documented in retinal arterioles and venules, these responses have yet to be quantified in the smallest vessels of the human retina. Here, using in vivo adaptive optics, we imaged 3-25 µm diameter vessels of the human inner retinal circulation and monitored the effects of altered gas-breathing conditions. During isocapnic hyperoxia, definite constrictions were seen in 51% of vessel segments (mean ± SD for pre-capillary arterioles -9.5 ± 3.0%; capillaries -11.8 ± 3.3%; post-capillary venules -6.3 ± 2.8%); these are comparable with responses previously reported in larger vessels. During isoxic hypercapnia, definite dilations were seen in 47% of vessel segments (mean ± SD for pre-capillary arterioles +9.8 ± 1.5%; capillaries +13.7 ± 3.8%; post-capillary venules +7.5 ± 4.2%); these are proportionally greater than responses previously reported in larger vessels. The magnitude of these proportional changes implies that the capillary beds themselves play an important role in the retinal response to changes in carbon dioxide levels. Interestingly, the distribution of microvascular responses shown here differs from our previously reported responses to flicker stimu...Continue Reading

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Citations

Jul 6, 2019·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Guodong LiuBang V Bui
Sep 12, 2020·PloS One·Maxwell SingerAmir H Kashani
Jun 8, 2019·Investigative Ophthalmology & Visual Science·Bright S AshimateyAmir H Kashani
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Aug 1, 2020·Optics Letters·Phillip Bedggood, Andrew Metha
Dec 2, 2020·Eye·Engin AkyolAndrew J Lotery
Jan 19, 2021·Progress in Retinal and Eye Research·Amir H KashaniJohn M Ringman
Aug 4, 2021·Translational Vision Science & Technology·Farzan AbdolahiAmir H Kashani
Jun 26, 2021·Annual Review of Vision Science·Stephen A BurnsThomas J Gast
Dec 1, 2021·Investigative Ophthalmology & Visual Science·Raymond L WarnerStephen A Burns

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