Reactivity, Mechanism, and Assembly of the Alternative Nitrogenases.

Chemical Reviews
Andrew J JasniewskiYilin Hu

Abstract

Biological nitrogen fixation is catalyzed by the enzyme nitrogenase, which facilitates the cleavage of the relatively inert triple bond of N2. Nitrogenase is most commonly associated with the molybdenum-iron cofactor called FeMoco or the M-cluster, and it has been the subject of extensive structural and spectroscopic characterization over the past 60 years. In the late 1980s and early 1990s, two "alternative nitrogenase" systems were discovered, isolated, and found to incorporate V or Fe in place of Mo. These systems are regulated by separate gene clusters; however, there is a high degree of structural and functional similarity between each nitrogenase. Limited studies with the V- and Fe-nitrogenases initially demonstrated that these enzymes were analogously active as the Mo-nitrogenase, but more recent investigations have found capabilities that are unique to the alternative systems. In this review, we will discuss the reactivity, biosynthetic, and mechanistic proposals for the alternative nitrogenases as well as their electronic and structural properties in comparison to the well-characterized Mo-dependent system. Studies over the past 10 years have been particularly fruitful, though key aspects about V- and Fe-nitrogenases r...Continue Reading

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Citations

Jul 28, 2020·Applied and Environmental Microbiology·Katja E LuxemXinning Zhang
May 20, 2020·Chembiochem : a European Journal of Chemical Biology·Yilin Hu, Markus W Ribbe
Sep 13, 2020·Chembiochem : a European Journal of Chemical Biology·Jasper LiedtkeYilin Hu
Jan 15, 2021·Chemical Communications : Chem Comm·Yuya Ashida, Yoshiaki Nishibayashi
Dec 16, 2020·Angewandte Chemie·Trixia M BuscaganThomas Spatzal
Jan 1, 2021·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Casey Van StappenSerena DeBeer
Mar 6, 2021·The Journal of Biological Chemistry·Michael S MedinaCedric P Owens
Oct 18, 2020·Journal of Inorganic Biochemistry·Derek F HarrisLance C Seefeldt
Apr 15, 2021·Inorganic Chemistry·Manuel Luca BesmerRoger Alberto
Apr 11, 2021·Proceedings of the National Academy of Sciences of the United States of America·Suppachai SrisantithamDaniel L M Suess
Apr 20, 2021·Journal of Inorganic Biochemistry·Daniel J DiPrimio, Patrick L Holland
Apr 29, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Anaïs CoffinetAntoine Simonneau
May 12, 2021·Chemical Reviews·Sebastian J K ForrestSven Schneider
Jun 24, 2021·Chemical Society Reviews·Chen-Hao Wang, Serena DeBeer
Jun 15, 2021·Chemical Science·Zhi-Yong YangLance C Seefeldt
Aug 28, 2021·International Journal of Molecular Sciences·Marco Larrea-Álvarez, Saul Purton
Oct 14, 2021·Chembiochem : a European Journal of Chemical Biology·Niels N Oehlmann, Johannes G Rebelein

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