Reactivity of antibodies from syphilis patients to a protein array representing the Treponema pallidum proteome

Journal of Clinical Microbiology
Mary Beth BrinkmanTimothy Palzkill

Abstract

To identify antigens important in the human immune response to syphilis, the serum antibody reactivity of syphilitic patients was examined with 908 of the 1,039 proteins in the proteome of Treponema pallidum subsp. pallidum using a protein array enzyme-linked immunosorbent assay. Thirty-four proteins exhibited significant reactivity when assayed with human sera from patients in the early latent stage of syphilis. A subset of antigens identified were further scrutinized for antibody reactivity at primary, secondary, and latent disease stages, and the results demonstrate that the humoral immune response to individual T. pallidum proteins develops at different rates during the time course of infection.

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Citations

Jun 9, 2009·Nature Reviews. Microbiology·Kirk W DeitschJames R Stringer
Apr 14, 2010·Infection and Immunity·Melanie A McGillSteven J Norris
Dec 15, 2010·Infection and Immunity·Simon HoustonCaroline E Cameron
Mar 12, 2008·Infection and Immunity·Mary Beth BrinkmanTimothy Palzkill
Dec 3, 2011·The Journal of Clinical Investigation·Emily L Ho, Sheila A Lukehart
May 11, 2010·European Journal of Medical Research·Xiaohui MoWeiming Gu
Jan 10, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Man XuYimou Wu
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Dec 27, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·David SmajsGeorge M Weinstock
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