Reactivity of isolated canine bronchus and pulmonary blood vessels to autonomic, autacoid agents and antigen

Agents and Actions
N Chand, P Eyre

Abstract

Adult dogs were sensitized to horse plasma. Reactivity of isolated bronchus and pulmonary blood vessels to antigen and some selected autonomic and autacoid agents were studied. Pulmonary veins contracted to bradykinin, 5-HT, PGF2alpha, PGE2, histamine, carbachol and antigen (Schultz-Dale reaction). Pulmonary arterial strips contracted to 5-HT and histamine, but only weakly to horse plasma. Bronchial strips contracted to carbachol, 5-HT, histamine and horse plasma, relaxed to isoprenaline, PGE1 and PGE2. Subsequent antigen challenge produced 'desensitization'. Allowing the tissues to 'rest' for 1 and 2 h resulted in partial 'recovery' of the anaphylactic response. This investigation suggests that the contractions of sensitized pulmonary vein and bronchus to specific antigen may contribute to the patho-physiology of pulmonary hypersensitivity in dogs.

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Citations

Oct 1, 1977·European Journal of Pharmacology·N Chand, P Eyre
Mar 1, 1978·The Journal of Pharmacy and Pharmacology·D T OkpakoP Eyre
Jul 1, 1978·The Journal of Pharmacy and Pharmacology·N Chand, P Eyre
Oct 1, 1978·Canadian Journal of Physiology and Pharmacology·C J Hanna, P Eyre
Jan 1, 1975·Annual Review of Pharmacology·P J KadowitzA L Hyman
Jun 1, 1977·The Journal of Clinical Investigation·W W Busse, J Sosman
Apr 1, 1978·Agents and Actions·N Chand, P Eyre
Apr 1, 1978·Agents and Actions·N Chand, P Eyre
Jan 1, 1977·British Journal of Pharmacology·N Chand, P Eyre
Jul 1, 1976·Agents and Actions·G A Persson, M Ekman
Aug 1, 1975·British Journal of Pharmacology·L S Dunlop, A P Smith
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Related Concepts

Histamine Measurement
KNG1
Bronchial System
Lung
Site-specific Telomere Resolvase Activity
Blood Vessel
Serotonin
Contraction (Finding)
Smooth Muscle
Bronchi

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