Reactivity of monoclonal antibodies with human myeloid precursor cells

British Journal of Haematology
D H CrawfordG Goldstein

Abstract

Five monoclonal antibodies have been tested for their ability to bind to myeloid precursor cells in normal human bone marrow. Indirect immunofluorescence and the fluorescence activated cell sorter was used to separate cells according to their reactivity for trial culture in vitro in order to grow granulocyte-macrophage colony forming cells (CFUc). Two antibodies (OKT3 and OKT11) which react strongly with bone marrow T lymphocytes were found to be unreactive with CFUc. YD1/23 reacts very strongly with both T and B lymphocytes but is only weakly reactive with CFUc. In contrast, OKT10 and YE2/36 did react with CFUc. The consequences of these findings and the potential clinical use of these antibodies in bone marrow transplantation are discussed.

References

Apr 24, 1975·The New England Journal of Medicine·E D ThomasC D Buckner
Oct 1, 1977·The Journal of Experimental Medicine·M J Cline, R Billing
Jan 1, 1977·Haematology and Blood Transfusion·H RodtS Thierfelder
Jun 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·E J YunisO Stutman
Aug 1, 1970·Journal of Cellular Physiology·B L Pike, W A Robinson
Jan 1, 1981·International Journal of Immunopharmacology·R H RubinM S Hirsch
Mar 1, 1981·Journal of Clinical Pathology·A V Hoffbrand, G Janossy
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
May 1, 1981·European Journal of Immunology·J W Oldfather, F W Chorpenning

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Citations

Nov 1, 1984·Journal of Clinical Immunology·R GerliS Davis
Jan 1, 1981·International Journal of Immunopharmacology·G JanossyG Goldstein
Jan 1, 1986·Critical Reviews in Oncology/hematology·C A Sieff
Apr 1, 1983·British Journal of Haematology·R GerliF Spinozzi
Mar 27, 1981·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·C Milstein
Jun 1, 1985·Japanese Journal of Medical Science & Biology·M Havredaki, F Barona
Dec 1, 1983·European Journal of Immunology·F KatzM Greaves
Dec 22, 2016·Oncoimmunology·Djordje AtanackovicTim Luetkens
Oct 28, 1986·Biochimica Et Biophysica Acta·C L Reading, Y Takaue

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