Reactivity of Nucleic Acid Radicals

Advances in Physical Organic Chemistry
Marc M Greenberg

Abstract

Nucleic acid oxidation plays a vital role in the etiology and treatment of diseases, as well as aging. Reagents that oxidize nucleic acids are also useful probes of the biopolymers' structure and folding. Radiation scientists have contributed greatly to our understanding of nucleic acid oxidation using a variety of techniques. During the past two decades organic chemists have applied the tools of synthetic and mechanistic chemistry to independently generate and study the reactive intermediates produced by ionizing radiation and other nucleic acid damaging agents. This approach has facilitated resolving mechanistic controversies and lead to the discovery of new reactive processes.

Citations

Nov 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jens Sobek, Ralph Schlapbach
Jan 15, 2021·Chemical Reviews·Nicolò Zuin FantoniTom Brown
Jun 1, 2021·Frontiers in Molecular Biosciences·Mikiei Tanaka, P Boon Chock
Oct 11, 2017·The Journal of Organic Chemistry·Huabing SunMarc M Greenberg
Jun 12, 2020·The Journal of Organic Chemistry·Liwei Zheng, Marc M Greenberg
May 9, 2018·Journal of the American Chemical Society·Liwei Zheng, Marc M Greenberg
Sep 2, 2021·Journal of the American Chemical Society·Haihui PengMarc M Greenberg

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