PMID: 25726783Jan 1, 2014Paper

Reactivity of perineuronal astrocytes in the prefrontal cortex in schizophrenia: an ultrastructural morphometric study

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
N A UranovaD D Orlovskaia

Abstract

Previously the ultrastructural alterations of astrocytes have been reported in schizophrenia. Reduced dendritic arborization of the neurons in layer 5 of the prefrontal cortex has been found in schizophrenia. Authors hypothesized that the abnormalities in perineuronal astrocytes (PA) might contribute to these neuronal changes. It was aimed to study the ultrastructure of PA in the prefrontal cortex in schizophrenia. Postmortem electron microscopic morphometric study of PA was performed in layer 5, area 10 of the prefrontal cortex in 39 cases of schizophrenia and 37 controls. No significant group differences were found in areas of cell, nucleus, cytoplasm, volume fraction (Vv) of lipofuscin granules and areal density of PA. However, in the subgroup of women with schizophrenia, the areal density of PA was significantly lower and the area of PA was significantly higher as compared to the subgroup of healthy women (-52%, p<0,01; +32%, p<0.05 respectively) and to the subgroup of men with schizophrenia (-56%, p<0,01; +23%, p<0,05 respectively). The area of PA nucleus was negatively correlated with the duration of disease (r= -0.37, p=0.02) and positively with the age of disease onset (ADO) (r=0,47, p<0,01). Areas of PA and of PA nucle...Continue Reading

References

Oct 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H J GundersenB Pakkenberg
Jan 1, 1974·Journal of Psychiatric Research·J M Davis
Dec 1, 1996·Hormones and Behavior·J A MongM M McCarthy
Apr 5, 2001·Journal of Psychiatric Research·J J ThuneB Pakkenberg
Sep 29, 2001·Brain Research Bulletin·N UranovaV Rachmanova
Oct 12, 2001·Glia·Y Dong, E N Benveniste
Oct 19, 2002·Science·R Douglas Fields, Beth Stevens-Graham
Feb 28, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Luc Pellerin, Pierre J Magistretti
Apr 2, 2004·The American Journal of Psychiatry·James E BlackWilliam T Greenough
Oct 12, 2004·Journal of Neurocytology·Alan Peters
Nov 16, 2004·Annals of the New York Academy of Sciences·Tetsuji SugaiHiroyuki Nawa
Nov 7, 2006·Neurochemistry International·Daniel KondziellaUrsula Sonnewald
Feb 23, 2007·The International Journal of Neuropsychopharmacology·Natalya A UranovaDiana D Orlovskaya
Jun 15, 2007·Schizophrenia Research·Victor M VostrikovDiana D Orlovskaya
Aug 3, 2007·International Review of Psychiatry·Marinos Kyriakopoulos, Sophia Frangou
Aug 25, 2007·Annual Review of Clinical Psychology·Deanna M Barch
Sep 14, 2007·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Victor VostrikovNatalya Uranova
Oct 16, 2007·Journal of the Neurological Sciences·Jacques De KeyserMarcus W Koch
Jun 20, 2008·Schizophrenia Research·Amy E SteffekJames H Meador-Woodruff
Mar 21, 2009·Trends in Pharmacological Sciences·Roberta Diaz Brinton
May 30, 2009·Brain : a Journal of Neurology·Gwenaëlle DouaudAnthony James
Jul 11, 2009·Expert Review of Neurotherapeutics·Hans-Gert BernsteinBernhard Bogerts
Jan 30, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Natalya A UranovaDiana D Orlovskaya
Mar 25, 2010·Neuroendocrinology·Paul MicevychJohn Kuo
Nov 3, 2010·Biological Psychiatry·Tatiana P Schnieder, Andrew J Dwork
Nov 3, 2010·Schizophrenia Bulletin·Korrapati V SathyasaikumarRobert Schwarcz
Jul 13, 2011·Biology of Sex Differences·María Santos-GalindoLuis M Garcia-Segura
Nov 11, 2011·Journal of Neuroendocrinology·R W IrwinR D Brinton
Dec 24, 2011·Neurobiology of Aging·Alan Peters, Thomas Kemper
Sep 25, 2012·Schizophrenia Research·Marieke J H BegemannIris E Sommer
Nov 23, 2012·The Journal of Comparative Neurology·Julie A MarkhamJames I Koenig
May 28, 2013·BMC Psychiatry·Kara O'ConnellKumlesh K Dev
Aug 6, 2013·Schizophrenia Research·Abigail H FerestenClare L Beasley
Aug 21, 2013·Schizophrenia Bulletin·Andrea GoudriaanMark H G Verheijen

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