Reactivity to sorbitan sesquioleate affects reactivity to fragrance mix I

Contact Dermatitis
J GeierWolfgang Uter

Abstract

Fragrance mix I (FM I) and its single constituents contain 5% and 1% sorbitan sesquioleate (SSO), respectively. SSO is a rare sensitizer and a potential irritant. To determine whether the outcome of the FM I breakdown test is affected by positive patch test reactivity to SSO. A retrospective analysis of data from the Information Network of Departments of Dermatology, 1998-2013, was performed. The full FM I breakdown test including SSO was tested in 2952 patients. Of these, 154 (5.2%) had a positive patch test reaction to SSO 20% pet. and 2709 (91.8%) had a negative patch test reaction. Positive reactions to one or more of the single fragrances contained in the mix were significantly more common (82.5% versus 57.3%) in SSO-positive patients, who also had more multiple reactions than FM I-positive patients with negative SSO reactions (61.5% versus 21.3% patients with reactions to two or more fragrances). Our results indicate that reactivity to SSO markedly affects the outcome of patch testing with FM I and its single constituents. SSO must be an obligatory part of the full FM I breakdown test, and should ideally be included in the baseline series.

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Citations

Jan 26, 2016·Contact Dermatitis·Niels Højsager Bennike, Jeanne Duus Johansen
Aug 9, 2015·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·J Geier, W Uter
Jan 23, 2020·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·J Geier, R Brans
Aug 23, 2019·Dermatitis : Contact, Atopic, Occupational, Drug·Anton C de Groot
Feb 4, 2021·Contact Dermatitis·Johannes GeierUNKNOWN Information Network of Departments of Dermatology

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