Read-through therapy for mitochondrial DNA nonsense mutations

Drug Discovery Today
David Pacheu-GrauEduardo Ruiz-Pesini

Abstract

Disorders resulting from mitochondrial DNA (mtDNA) mutations, including nonsense mutations, do not yet have causal treatments. As we discuss here, read-through therapies appear to be a promising approach to the treatment of disorders arising from nuclear DNA (nDNA) nonsense mutations. The genetics of mitochondrial DNA suggest that this therapy will also be successful in the treatment of mitochondriopathies.

References

Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B G BarrellI G Young
Apr 9, 1981·Nature·S AndersonI G Young
Aug 27, 1998·Molecular Biology and Evolution·A ReyesC Saccone
Aug 17, 1999·The Journal of Clinical Investigation·E R Barton-DavisH L Sweeney
May 22, 2003·Biochimica Et Biophysica Acta·Michaela Nilsson, Monica Rydén-Aulin
Jul 15, 2003·Clinical Microbiology Reviews·Sergei B Vakulenko, Shahriar Mobashery
Mar 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·L GORINI, E KATAJA
Nov 5, 2003·The Journal of Clinical Investigation·Robert W TaylorDouglass M Turnbull
May 24, 2006·Biochimie·T DaviterM V Rodnina
May 6, 2008·Human Mutation·Matthew MortNadia A Chuzhanova
May 17, 2008·Biochemical Society Transactions·Agnieszka J BobrowiczZofia Chrzanowska-Lightowlers
Oct 9, 2008·Biochimica Et Biophysica Acta·Julio MontoyaEduardo Ruiz-Pesini
Oct 15, 2008·Human Mutation·Mannis van Oven, Manfred Kayser
Jan 16, 2010·Science·Richard TemperleyZofia M Chrzanowska-Lightowlers
Aug 25, 2010·Biochimica Et Biophysica Acta·María Pilar Bayona-BafaluyEduardo Ruiz-Pesini
Dec 15, 2010·Nucleic Acids Research·Célia FloquetLaure Bidou
Aug 23, 2011·Molecular Oncology·Xiao Wang, Carlos T Moraes
Oct 7, 2011·Wiley Interdisciplinary Reviews. RNA·Kim M Keeling, David M Bedwell

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