Reading the unique DNA methylation landscape of the brain: Non-CpG methylation, hydroxymethylation, and MeCP2

Proceedings of the National Academy of Sciences of the United States of America
Benyam KindeMichael E Greenberg

Abstract

DNA methylation at CpG dinucleotides is an important epigenetic regulator common to virtually all mammalian cell types, but recent evidence indicates that during early postnatal development neuronal genomes also accumulate uniquely high levels of two alternative forms of methylation, non-CpG methylation and hydroxymethylation. Here we discuss the distinct landscape of DNA methylation in neurons, how it is established, and how it might affect the binding and function of protein readers of DNA methylation. We review studies of one critical reader of DNA methylation in the brain, the Rett syndrome protein methyl CpG-binding protein 2 (MeCP2), and discuss how differential binding affinity of MeCP2 for non-CpG and hydroxymethylation may affect the function of this methyl-binding protein in the nervous system.

References

Feb 1, 1972·The Biochemical Journal·N W PennR Yura
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·B H RamsahoyeR Jaenisch
Jan 10, 2002·Genes & Development·Adrian Bird
May 5, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Suzanne NguyenRudolf Jaenisch
Nov 9, 2007·Neuron·Maria Chahrour, Huda Y Zoghbi
May 9, 2008·Nature Reviews. Genetics·Miho M Suzuki, Adrian Bird
Mar 11, 2009·Genome Research·Ryan Lister, Joseph R Ecker
Apr 18, 2009·Science·Skirmantas Kriaucionis, Nathaniel Heintz
Oct 6, 2010·Advances in Genetics·Marta Kulis, Manel Esteller
Nov 19, 2010·Organic Letters·Martin MünzelThomas Carell
Apr 22, 2011·Progress in Molecular Biology and Translational Science·Pierre-Antoine Defossez, Irina Stancheva
Jul 5, 2011·Annual Review of Cell and Developmental Biology·Jacky GuyAdrian Bird
Jul 8, 2011·Genome Biology·Pao-Yang ChenMatteo Pellegrini
Nov 1, 2011·Nature Neuroscience·Keith E SzulwachPeng Jin
Dec 17, 2011·PLoS Genetics·Michael J ZillerAlexander Meissner
Mar 1, 2012·Nucleic Acids Research·Hideharu HashimotoXiaodong Cheng
Dec 1, 2012·Nature Protocols·Miao YuChuan He
Feb 13, 2013·Nature Reviews. Genetics·Zachary D Smith, Alexander Meissner
Feb 26, 2013·Cell·Cornelia G SpruijtMichiel Vermeulen
Jun 19, 2013·Cell Stem Cell·Run-Rui ZhangGuo-Liang Xu
Jun 19, 2013·Nature Neuroscience·Matthew J LystAdrian Bird
Jul 6, 2013·Science·Ryan ListerJoseph R Ecker
Aug 9, 2013·Nature·Michael J ZillerAlexander Meissner

❮ Previous
Next ❯

Citations

Feb 5, 2016·Alcoholism, Clinical and Experimental Research·David P GavinSubhash C Pandey
Nov 18, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Marie Anaïs LabouesseUrs Meyer
Feb 2, 2016·Schizophrenia Research·John F FullardPanos Roussos
Dec 29, 2015·Analytical Chemistry·Xiang-Cheng LinJian-Hui Jiang
Oct 31, 2015·Genes, Brain, and Behavior·Cathy L Barr, Virginia L Misener
Jan 2, 2016·American Journal of Epidemiology·Huihuang YanTamas Ordog
Oct 21, 2015·Frontiers in Immunology·Kate H Brettingham-MooreAdele F Holloway
Oct 1, 2015·Science Signaling·Erin A Clark, Sacha B Nelson
Mar 10, 2016·Human Molecular Genetics·Rebecca A G De SouzaBlair R Leavitt
Aug 19, 2015·Frontiers in Neuroscience·Ryan Lister, Eran A Mukamel
Jun 3, 2015·Proceedings of the National Academy of Sciences of the United States of America·Eric B KeverneInna Tabansky
Jun 15, 2016·Briefings in Functional Genomics·Floriana Della RagioneMaurizio D'Esposito
Jun 22, 2016·Molecular Neurobiology·Yu-Jie LaiGuo-Jun Chen
Jul 1, 2016·Epigenetics & Chromatin·Wai-Shin YongPao-Yang Chen
Oct 28, 2016·Nature Neuroscience·Alexi NottLi-Huei Tsai
Aug 2, 2016·Nature Reviews. Genetics·Heng ZhuJiang Qian
Aug 9, 2016·Chemical Reviews·Alexander C Drohat, Christopher T Coey
Aug 23, 2016·Neurobiology of Learning and Memory·Michael J MorrisLisa M Monteggia
Sep 2, 2016·Nucleic Acids Research·Christopher T CoeyAlexander C Drohat
Sep 7, 2016·Nucleic Acids Research·Hideharu HashimotoXiaodong Cheng
Jul 15, 2016·Briefings in Functional Genomics·Mònica SuelvesMiguel A Peinado
Oct 26, 2016·Development and Psychopathology·Elena L GrigorenkoOksana Yu Naumova
Nov 12, 2016·Neuroscience and Biobehavioral Reviews·Bhaskar Roy, Yogesh Dwivedi
Dec 6, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Yong-Hwee Eddie LohHongyan Zou
Jan 4, 2017·Molecular Psychiatry·R Delgado-Morales, M Esteller
Jan 23, 2017·Biophysical Journal·Csaba I PongorMiklós Kellermayer
Feb 18, 2017·Genes·Joyce Keifer
May 16, 2017·Genes·Maria Fasolino, Zhaolan Zhou
Apr 8, 2017·International Journal of Molecular Sciences·Ariel Cariaga-Martinez, Raúl Alelú-Paz
Jan 28, 2017·Pain·Franziska Denk, Stephen B McMahon
Jan 24, 2017·Neuroscience Letters·K Kobow, I Blümcke
Jul 12, 2017·Molecular Psychiatry·P-E LutzG Turecki
Sep 28, 2017·Aging Cell·Dustin R MasserWillard M Freeman
Mar 24, 2018·The Journal of Biological Chemistry·Ke LiuJinrong Min
Jun 12, 2018·Expert Opinion on Therapeutic Targets·Santiago HaaseMaria G Castro
Nov 10, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Stefania CiafrèMauro Ceccanti
Jan 18, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jin GaoJack T Rogers
Dec 27, 2018·The European Journal of Neuroscience·Matthew E GloverSarah M Clinton
Jan 13, 2018·GeroScience·Dustin R MasserWillard M Freeman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.