Readmission and mortality in malnourished, older, hospitalized adults treated with a specialized oral nutritional supplement: A randomized clinical trial

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Nicolaas E DeutzNOURISH Study Group

Abstract

Hospitalized, malnourished older adults have a high risk of readmission and mortality. Evaluation of a high-protein oral nutritional supplement (HP-HMB) containing beta-hydroxy-beta-methylbutyrate on postdischarge outcomes of nonelective readmission and mortality in malnourished, hospitalized older adults. Multicenter, randomized, placebo-controlled, double-blind trial. Inpatient and posthospital discharge. Older (≥65 years), malnourished (Subjective Global Assessment [SGA] class B or C) adults hospitalized for congestive heart failure, acute myocardial infarction, pneumonia, or chronic obstructive pulmonary disease. Standard-of-care plus HP-HMB (n = 328) or a placebo supplement (n = 324), 2 servings/day. Primary composite endpoint was 90-day postdischarge incidence of death or nonelective readmission. Other endpoints included 30- and 60-day postdischarge incidence of death or readmission, length of stay (LOS), SGA class, body weight, and activities of daily living (ADL). The primary composite endpoint was similar between HP-HMB (26.8%) and placebo (31.1%). No between-group differences were observed for 90-day readmission rate, but 90-day mortality was significantly lower with HP-HMB relative to placebo (4.8% vs. 9.7%; relative...Continue Reading

References

Jan 1, 1970·The Gerontologist·S KatzR C Grotz
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·A M ScholsE F Wouters
Jun 8, 1999·JAMA : the Journal of the American Medical Association·D H SullivanR C Walls
Aug 5, 2006·The American Journal of Medicine·Salah GariballaHilary Powers
Mar 3, 2009·Annals of Nutrition & Metabolism·R GirónJ Ancochea
Jul 17, 2009·The New England Journal of Medicine·Eric C Rackow
Sep 26, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T LangT B Harris
Oct 13, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Juliane StarkeRémy Meier
Mar 8, 2011·JPEN. Journal of Parenteral and Enteral Nutrition·Meena SomanchiGerard E Mullin
Nov 30, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Su Lin LimLynne Daniels
Jan 20, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Gary P HubbardRebecca J Stratton
Jul 24, 2012·Age and Ageing·Fredrik TossAnna Nordström
Jan 17, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Joseph S Hanna
Feb 3, 2015·JAMA Internal Medicine·S Ryan GreysenKenneth E Covinsky
Aug 27, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M EliaK Norman

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Citations

Apr 18, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Everson A Nunes, Stuart M Phillips
Apr 20, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Nicolaas E DeutzUNKNOWN NOURISH Study Group
May 22, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Gulistan BahatMehmet Akif Karan
May 23, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Gozde Sengul AycicekZekeriya Ulger
May 26, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Alessandro Laviano
May 22, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lina JohanssonUNKNOWN European Renal Nutrition (ERN) Working Group of the European Renal Association–European Dialysis Transplant Association (ERA
Aug 16, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ione de Brito-Ashurst, Arthur R H van Zanten
Aug 6, 2016·Applied Health Economics and Health Policy·Yue ZhongPeter J Neumann
Oct 27, 2016·Journal of the American Medical Directors Association·John E Morley
Sep 23, 2016·PloS One·Scott GoatesMary Beth Arensberg
Dec 8, 2016·JPEN. Journal of Parenteral and Enteral Nutrition·Krishnan SriramWm Thomas Summerfelt
Feb 7, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Mariëlle P K J Engelen, Nicolaas E P Deutz
Dec 21, 2016·The Cochrane Database of Systematic Reviews·Christine BaldwinChristine Elizabeth Weekes
Feb 6, 2018·Journal of Clinical Nursing·Sandra M G ZwakhalenMarieke J Schuurmans
Feb 3, 2018·Nutrition & Dietetics : the Journal of the Dietitians Association of Australia·Adrienne M YoungElisabeth Isenring
Oct 26, 2018·Molecular Nutrition & Food Research·Mensiena B G KiewietPau de Vos
May 28, 2019·JPEN. Journal of Parenteral and Enteral Nutrition·Kensuke NakamuraNaoto Morimura
May 1, 2019·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·M BrooksM Papas
Mar 25, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Rachel R DeerElena Volpi
Dec 27, 2019·Journal of Clinical Nursing·Debbie Ten CateUNKNOWN Basic Care Revisited Group (BCR)
Apr 14, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Angel F ValladaresSharon McCauley
Jun 4, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·David G A WilliamsPaul E Wischmeyer
Dec 22, 2016·Current Opinion in Clinical Nutrition and Metabolic Care·Filippo G Di GirolamoGianni Biolo
Nov 30, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Francesco LandiEmanuele Marzetti
Apr 25, 2019·Heart Failure Reviews·Anna WawrzeńczykJacek Budzyński
Jul 3, 2019·Journal of Clinical Medicine·Mette M BergerNawfel Ben-Hamouda
Jul 13, 2019·Journal of Clinical Medicine·Emilie ReberZeno Stanga
Feb 18, 2020·Annals of Internal Medicine·Philipp Schuetz, Jeffrey L Greenwald
Jan 4, 2018·Critical Care : the Official Journal of the Critical Care Forum·Paul E Wischmeyer
Dec 20, 2018·JPEN. Journal of Parenteral and Enteral Nutrition·Brett R LomanUNKNOWN NOURISH Study Group

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