Reaffirming the link between chronic phantom limb pain and maintained missing hand representation

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Sanne KikkertTamar R Makin

Abstract

Phantom limb pain (PLP) is commonly considered to be a result of maladaptive brain plasticity. This model proposes that PLP is mainly caused by reorganisation in the primary somatosensory cortex, presumably characterised by functional degradation of the missing hand representation and remapping of other body part representations. In the current study, we replicate our previous results by showing that chronic PLP correlates with maintained representation of the missing hand in the primary sensorimotor missing hand cortex. We asked unilateral upper-limb amputees to move their phantom hand, lips or other body parts and measured the associated neural responses using functional magnetic resonance imaging (fMRI). We confirm that amputees suffering from worse chronic PLP have stronger activity in the primary sensorimotor missing hand cortex while performing phantom hand movements. We find no evidence of lip representation remapping into the missing hand territory, as assessed by measuring activity in the primary sensorimotor missing hand cortex during lip movements. We further show that the correlation between chronic PLP and maintained representation of the missing hand cannot be explained by the experience of chronic non-painful pha...Continue Reading

Citations

Oct 23, 2018·PloS One·Jean-Daniel DuboisCatherine Mercier
Nov 2, 2018·Annals of Neurology·Sanne KikkertTamar R Makin
Dec 11, 2019·Journal of Clinical Medicine·Erik LeemhuisAnd Mariella Pazzaglia
May 7, 2020·Regional Anesthesia and Pain Medicine·Joel P CastellanosTimothy Furnish
Mar 17, 2020·Pain Practice : the Official Journal of World Institute of Pain·Marionna MüngerFelipe Fregni
Jul 31, 2019·Current Pain and Headache Reports·Ivan UritsOmar Viswanath
May 7, 2020·Frontiers in Neuroscience·Muhammed Enes GunduzFelipe Fregni
Jul 28, 2020·Brain Imaging and Behavior·Ayhan ŞavklıyıldızÖmer Halil Çolak
Aug 28, 2020·Frontiers in Neurology·Ludmilla Candido SantosFelipe Fregni
Oct 21, 2020·Physiotherapy Theory and Practice·Andrew GrahamDenis J Martin
Sep 9, 2020·PM & R : the Journal of Injury, Function, and Rehabilitation·Ellie BalakhanlouLinda Resnik
Jun 3, 2020·Journal of Hand Therapy : Official Journal of the American Society of Hand Therapists·Hunter G HoffmanStephen W Pitt
May 6, 2021·Journal of Neurophysiology·Amanda S TherrienLaurel J Buxbaum
May 29, 2021·Neuropsychiatric Disease and Treatment·Shuang JiangGang Zhu
Jun 9, 2021·Neural Regeneration Research·M Ángeles Garcia-PalleroPablo Roman
Oct 28, 2021·Neurorehabilitation and Neural Repair·Elisabetta AmbronH Branch Coslett

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Methods Mentioned

BETA
amputation
amputations
dissect

Software Mentioned

FMRIB
FSL
Prisma
Linear Image Registration Tool [ MCFLIRT
Linear Image Registration Tool [ FLIRT
Matlab
SPSS
Verio
Expert Analysis Tool FEAT
BET

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