Reagent- and separation-free measurements of urine creatinine concentration using stamping surface enhanced Raman scattering (S-SERS)

Biomedical Optics Express
Ming LiWei-Chuan Shih

Abstract

We report a novel reagent- and separation-free method for urine creatinine concentration measurement using stamping surface enhanced Raman scattering (S-SERS) technique with nanoporous gold disk (NPGD) plasmonic substrates, a label-free, multiplexed molecular sensing and imaging technique recently developed by us. The performance of this new technology is evaluated by the detection and quantification of creatinine spiked in three different liquids: creatinine in water, mixture of creatinine and urea in water, and creatinine in artificial urine within physiologically relevant concentration ranges. Moreover, the potential application of our method is demonstrated by creatinine concentration measurements in urine samples collected from a mouse model of nephritis. The limit of detection of creatinine was 13.2 nM (0.15 µg/dl) and 0.68 mg/dl in water and urine, respectively. Our method would provide an alternative tool for rapid, cost-effective, and reliable urine analysis for non-invasive diagnosis and monitoring of renal function.

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Citations

Oct 31, 2015·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Leo T H de JeerJeff Th M De Hosson
Aug 23, 2016·IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-optics Society·Daniel ShirAydogan Ozcan
Nov 1, 2016·ACS Applied Materials & Interfaces·Suyan QiuWei-Chuan Shih
Oct 11, 2017·Nanomedicine·Md Masud Parvez Arnob, Wei-Chuan Shih
Feb 6, 2018·Reviews in Analytical Chemistry·Anh H NguyenZachary D Schultz
Mar 7, 2016·Optics Express·Christopher A R ChapmanManyalibo J Matthews
Oct 16, 2018·Biomedical Optics Express·Yudong LuShangyuan Feng
Oct 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kevin V HackshawLuis Rodriguez-Saona
Aug 18, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Chutiparn LertvachirapaiboonKeizo Kato
Nov 3, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Chutiparn LertvachirapaiboonKeizo Kato
Dec 12, 2018·ACS Sensors·Onur DurucanAnja Boisen
Sep 20, 2017·ACS Applied Materials & Interfaces·Cheng XingYijian Jiang

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