Real impact of liver cirrhosis on the development of hepatocellular carcinoma in various liver diseases-meta-analytic assessment

Cancer Medicine
Kazuo TaraoKatsuaki Tanaka

Abstract

It is well known that the incidence of developing hepatocelluler carcinoma (HCC) is increased in liver cirrhosis of different etiologies. However, comparison of HCC incidence in various liver diseases has not yet been estimated. We surveyed this comparison. The PubMed database was examined (1989-2017) for studies published in English language regarding the prospective follow-up results for the development of HCC in various liver diseases. A meta-analysis was performed for each liver disease. The annual incidence (%) of HCC in the non-cirrhotic stage and cirrhotic stage, and the ratio of HCC incidence in the cirrhotic stage/non-cirrhotic stage were as follows. (a) hepatitis B virus liver disease: 0.37%→3.23% (8.73-fold), (b) hepatitis C virus liver diseases: 0.68%→4.81% (7.07-fold), (c) primary biliary cholangitis (0.26%→1.79%, 6.88-fold), (d) autoimmune hepatitis (0.19%→0.53%, 2.79-fold), and (e) NASH (0.03%→1.35%, 45.00-fold). Regarding primary hemochromatosis and alcoholic liver diseases, only follow-up studies in the cirrhotic stage were presented, 1.20% and 2.06%, respectively. When the liver diseases advance to cirrhosis, the incidence of HCC is markedly increased. The development of HCC must be closely monitored by ultras...Continue Reading

References

Apr 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S FargionD Conte
Jan 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E E PowellL W Powell
Nov 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K K Wang, A J Czaja
Nov 14, 1985·The New England Journal of Medicine·C NiederauG Strohmeyer
Aug 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M ShermanC Lee
Mar 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S TakanoM Omata
Dec 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y M DeugnierJ W Halliday
Apr 1, 1996·Gastroenterology·C NiederauG Strohmeyer
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S BrunoM U Mondelli
Nov 15, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D E JonesO F James
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L SerfatyR Poupon
Aug 8, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S C GordonA L Silverman
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C NiederauD Häussinger
Apr 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P K NijhawanK D Lindor
Apr 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A FloreaniR Naccarato
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D C VallaP Opolon
Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V Di MarcoA Craxì
Jun 27, 2000·Australian and New Zealand Journal of Medicine·U DuttaG C Farrell
Dec 16, 2000·Digestive Diseases and Sciences·S Z ParkA J Czaja
Mar 7, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L FracanzaniS Fargion
Nov 17, 2001·American Journal of Clinical Pathology·M MorcosB Terris
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Akitaka ShibuyaToshio Morizane
Nov 12, 2002·The American Journal of Gastroenterology·Giovanna FattovichUNKNOWN European Concerted Action on Viral Hepatitis (EUROHEP)
Feb 26, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rosario F VelázquezLuis Rodrigo
Apr 25, 2003·The New England Journal of Medicine·Eugenia E CalleMichael J Thun
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jason M HuiJacob George

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Citations

May 27, 2020·The American Journal of Gastroenterology·Meaghan PhippsJulia Wattacheril
Jul 20, 2019·Therapeutic Advances in Medical Oncology·Ana LleoMassimo Colombo
Jun 21, 2020·International Journal of Environmental Research and Public Health·Shan-Han HuangChun-Wei Tung
Feb 9, 2020·Gastroenterology Clinics of North America·Naga Swetha SamjiSanjaya K Satapathy
Feb 12, 2020·Journal of Hepatology·Miryam MüllerJean-Charles Nault
Mar 26, 2021·Journal of Viral Hepatitis·Yi DongPan Zhao
Apr 17, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Thanida TangjarusritaratornTada Kunavisarut
May 7, 2021·Frontiers in Immunology·Yara O AghabiZania Stamataki
Sep 11, 2021·Nature Reviews. Gastroenterology & Hepatology·Terence Kin-Wah LeeStephanie Ma
Oct 12, 2021·Expert Review of Gastroenterology & Hepatology·Mohadeseh NaseriJavad Zahiri
Jan 4, 2022·Clinical Orthopaedics and Related Research·Dennis HundersmarckMarilyn Heng

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