Real-life effectiveness of once-daily calcipotriol and betamethasone dipropionate gel vs. ointment formulations in psoriasis vulgaris: final analysis of the 52-week PRO-long study

Journal of the European Academy of Dermatology and Venereology : JEADV
J LambertJ Vink

Abstract

Topical therapies are the mainstay of treatment for psoriasis vulgaris. The fixed combination of calcipotriol (Cal) 50 μg/g plus betamethasone 0.5 mg/g (as dipropionate; BD) is a first-line topical treatment and available as a gel or ointment. The use of these fixed combination products was compared in PRO-long, a long-term noninterventional study, for which interim results (4 and 12 weeks) have previously been reported. To describe and compare patients' perspectives on the fixed combination gel and ointment formulations; to include efficacy, adherence behaviour, treatment satisfaction and health-related quality of life (HRQoL) aspects during long-term real-life psoriasis management. PRO-long was a multicentre, prospective, observational, 52-week study of patients prescribed fixed combination Cal/BD gel or ointment in clinical practice. For final analysis the following were assessed at weeks 24, 36 and 52: differences in the proportion of patients with 'mild'/'very mild' disease according to patient's global assessment of disease severity, adherence behaviour, treatment satisfaction (nine-item treatment satisfaction questionnaire for medication) and HRQoL (Skindex-29). Patients (n = 328) were prescribed once-daily Cal/BD gel (n...Continue Reading

References

Aug 25, 1999·Journal of the American Academy of Dermatology·S R RappD M Reboussin
Oct 20, 2004·The British Journal of Dermatology·C L CarrollR Balkrishnan
May 6, 2005·The New England Journal of Medicine·Michael P Schön, W-Henning Boehncke
Aug 5, 2005·The New England Journal of Medicine·Lars Osterberg, Terrence Blaschke
Aug 27, 2005·The New England Journal of Medicine·Miguel G Madariaga
Nov 4, 2005·The New England Journal of Medicine·Ronald J Campbell
Dec 14, 2005·American Journal of Clinical Dermatology·Alexa B KimballYing Wu
Dec 21, 2005·Archives of Dermatology·Joel M GelfandDavid J Margolis
May 19, 2006·Dermatology : International Journal for Clinical and Investigative Dermatology·Torsten Schäfer
May 15, 2007·Journal of the American Academy of Dermatology·Steven R FeldmanRajesh Balkrishnan
Jul 31, 2007·Lancet·Christopher Em Griffiths, Jonathan Nwn Barker
Oct 5, 2007·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Oleg E AkilovTayyaba Hasan
Sep 13, 2008·Dermatology : International Journal for Clinical and Investigative Dermatology·T A LugerN H Shear
Oct 9, 2009·The Journal of Investigative Dermatology·James T ElderRajan P Nair
Apr 29, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·G Murphy, K Reich
Apr 29, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·A Bewley, B Page
May 26, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·C PaulJ-P Ortonne
May 26, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·S DevauxC Paul
Apr 2, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·E DaudénK Reich

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Citations

Apr 20, 2016·Expert Review of Clinical Pharmacology·Kevin C KinSteven R Feldman
May 11, 2016·Expert Opinion on Drug Delivery·Melissa B HoffmanSteven R Feldman
Apr 19, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·L IversenD Thaci
Feb 15, 2018·Archives of Dermatological Research·Aleksandra G FlorekApril W Armstrong
Feb 25, 2020·The Journal of Dermatological Treatment·Siegfried SegaertMelinda Gooderham
Apr 4, 2020·Expert Opinion on Drug Safety·Victoria Amat-Samaranch, Lluís Puig
Jun 2, 2020·Expert Review of Clinical Immunology·Matteo MegnaGabriella Fabbrocini
Sep 24, 2020·Advances in Therapy·Linda Stein GoldUNKNOWN PSO-LONG Trial Investigators
Dec 29, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Melissa KirkbyGary P Moss
Jan 16, 2021·Patient Preference and Adherence·Yi ZhaoKazi Deluwar Ahmed
May 5, 2021·The Journal of Dermatological Treatment·Claire BarkPer Svangren
Jan 7, 2021·Dermatology : International Journal for Clinical and Investigative Dermatology·Julia-Tatjana MaulAlexander A Navarini

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