Real-life experience of a stent-less revascularization strategy using a combination of excimer laser and drug-coated balloon for patients with acute coronary syndrome

Journal of Interventional Cardiology
Ayako HarimaYasuki Kihara

Abstract

We aimed to test a novel stent-less revascularization strategy using a combination of excimer laser coronary angioplasty (ELCA) and drug-coated balloon (DCB) for patients with acute coronary syndrome (ACS). Percutaneous coronary intervention with drug eluting stents is a standard invasive treatment for ACS. Some unsolved issues however remain, such as stent thrombosis and bleeding risks associated with dual antiplatelet therapy. Consecutive ACS patients were planned to receive either a DCB application following ELCA without a stent implantation or conventional revascularization with a coronary stent. The endpoints were (i) major cardiac adverse events (MACEs), defined as the composite of cardiac death, myocardial infarctions, and target lesion revascularization; (ii) target vessel revascularization (TVR); and (iii) angiographic outcome. Since a greater than expected number of patients allocated to the stent-less treatment arm eventually received a bailout stenting, the following 3 as-treated groups were compared; DCB with ELCA group (N = 60), Stent with ELCA group (N = 23), and Stent without ELCA group (N = 85). During a mean follow-up period of 420 ± 137 days, and with angiographic 6- and 12-month-follow-up rates of 96.7%, 87%...Continue Reading

References

Jan 1, 1993·Journal of the American College of Cardiology·R E KuntzD S Baim
Aug 4, 2001·Lasers in Medical Science·O TopazD Ebersole
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Ralf KösterThomas Meinertz
Mar 17, 2004·The American Journal of Cardiology·On TopazUNKNOWN CARMEL multicenter trial
Nov 15, 2006·The New England Journal of Medicine·Bruno SchellerUlrich Speck
May 2, 2007·Circulation·Donald E CutlipUNKNOWN Academic Research Consortium
Dec 17, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Alexandra LanskyUNKNOWN European Bifurcation Angiographic Sub-Committee
May 8, 2009·The New England Journal of Medicine·Gregg W StoneUNKNOWN HORIZONS-AMI Trial Investigators
Jul 25, 2009·Journal of Interventional Cardiology·Paolo GarronePierfrancesco Agostoni
Jan 18, 2013·The New England Journal of Medicine·Giulio G Stefanini, David R Holmes
Aug 29, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Franz X KleberBruno Scheller
Jun 30, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Freek NijhoffPieter R Stella
Jan 14, 2017·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Vittorio AmbrosiniAntonio Colombo
Jan 25, 2017·Journal of Interventional Cardiology·Tuomas T RissanenJaakko Eränen
Mar 10, 2017·Archives of Cardiovascular Diseases·Fabien PicardAnita W Asgar

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