Real-life GH dosing patterns in children with GHD, TS or born SGA: a report from the NordiNet® International Outcome Study

European Journal of Endocrinology
Oliver BlankensteinIsabelle Oliver Petit

Abstract

To describe real-life dosing patterns in children with growth hormone deficiency (GHD), born small for gestational age (SGA) or with Turner syndrome (TS) receiving growth hormone (GH) and enrolled in the NordiNet International Outcome Study (IOS; Nbib960128) between 2006 and 2016. This non-interventional, multicentre study included paediatric patients diagnosed with GHD (isolated (IGHD) or multiple pituitary hormone deficiency (MPHD)), born SGA or with TS and treated according to everyday clinical practice from the Czech Republic (IGHD/MPHD/SGA/TS: n = 425/61/316/119), France (n = 1404/188/970/206), Germany (n = 2603/351/1387/411) and the UK (n = 259/60/87/35). GH dosing was compared descriptively across countries and indications. Proportions of patients by GH dose group (low/medium/high) or GH dose change (decrease/increase/no change) during years 1 and 2 were also evaluated across countries and indications. In the Czech Republic, GH dosing was generally within recommended levels. In France, average GH doses were higher for patients with IGHD, MPHD and SGA than in other countries. GH doses in TS tended to be at the lower end of the recommended label range, especially in Germany and the UK; the majority of patients were in the ...Continue Reading

References

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Citations

Apr 14, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Michel PolakMarta Šnajderová
Nov 14, 2018·Aesthetic Surgery Journal·Manuel Chacón QuirósJeffry James Fassero
Jul 16, 2019·The Journal of Clinical Endocrinology and Metabolism·Lars SävendahlJudith Ross
Apr 4, 2018·Annals of Pediatric Endocrinology & Metabolism·Sochung ChungKee-Hyoung Lee
Nov 8, 2019·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Andreas KrebsKarl Otfried Schwab
Aug 16, 2018·Prilozi·Aleksandra JanchevskaZoran Gucev
Mar 6, 2019·Hormone Research in Pædiatrics·Tilman R RohrerDr Sabine Clips-Kastner Ferring Arzneimittel GmbH

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Methods Mentioned

BETA
SGA

Software Mentioned

SAS
GrowthWin
NordiNet

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