Real life patterns of care and progression free survival in metastatic renal cell carcinoma patients: retrospective analysis of cross-sectional data

BMC Cancer
Rana MarounIsabelle Durand-Zaleski

Abstract

Patient characteristics and survival outcomes in randomized trials may be different from those in real-life clinical practice. The objective of this study was to describe treatment pathways, safety, drug costs and survival in patients with metastatic Renal Cell Carcinoma (mRCC) in a real world setting. A retrospective analysis was performed using IQVIA real world oncology cross-sectional survey data, a retrospective treatment database collecting anonymized patient-level data in Europe. Data on treatment naïve patients with mRCC who received a first-line targeted therapy in France were extracted for the period 2005-2015. Descriptive analyses were performed on treatment patterns, patient characteristics and safety profiles. Progression Free Survival (PFS) was determined using Kaplan-Meier survival analysis. One thousand three hundred thirty-one patients with mRCC who received a first-line targeted therapy were included. The male/female sex ratio was 2.5 and 66% of patients were aged > 60 years. 83% of patients had clear cell adenocarcinoma. 83% of patients underwent a surgical procedure, 10% had radiotherapy. In patients who received a first-line targeted therapy, 73% received sunitinib. The mean time from diagnosis to first-line...Continue Reading

References

Jan 12, 2007·The New England Journal of Medicine·Robert J MotzerRobert A Figlin
Jan 12, 2007·The New England Journal of Medicine·Bernard EscudierUNKNOWN TARGET Study Group
Sep 25, 2007·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Louis P GarrisonC Daniel Mullins
Jun 3, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J MotzerRobert A Figlin
Jul 21, 2009·The Lancet Oncology·Martin E GoreRonald Bukowski
Aug 24, 2013·The New England Journal of Medicine·Robert J MotzerToni K Choueiri
Dec 3, 2014·Clinical Genitourinary Cancer·Daniel M GeynismanYa-Chen Tina Shih
Jan 27, 2015·European Urology·Borje LjungbergAxel Bex
Jul 25, 2015·BJU International·Daphne DayBen Tran
Sep 18, 2015·Frontiers in Oncology·Miriam Argyropulo-PalmerDavid Montgomery
Oct 23, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J WagstaffS Buchan
Dec 25, 2016·The Breast : Official Journal of the European Society of Mastology·Paolo MarchettiJan Lewis

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