Real-time conductivity imaging of temperature and tissue property changes during radiofrequency ablation: an ex vivo model using weighted frequency difference

Bioelectromagnetics
Hun WiTong In Oh

Abstract

We demonstrated the feasibility of time difference and weighted frequency difference conductivity imaging for real-time monitoring of temperature distribution and ablation region estimation during radiofrequency (RF) ablation. The electrical conductivity spectrum of biological tissue reflects mobility of ions in intra- and extra-cellular fluids and changes in cellular morphology induced by heating. The time series conductivity spectra were measured in an ex vivo bovine liver by a high-speed electrical impedance tomography (EIT) system. The EIT system was protected by filters to suppress RF energy and allow interleaved real-time imaging. We recorded time and weighted frequency-difference conductivity images and direct temperature variations at the ablation region and control region during 8 min ablation and for the following 66 min of cooling. Conductivity variation in regions of interest was compared with temperature recordings. Contours of conductivity change were visualized and compared to estimate the ablation area. EIT images confirmed increase of conductivity at all frequencies and loss of frequency conductivity change associated with loss of cellular structure. Time difference conductivity images showed changes due to bot...Continue Reading

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Citations

Jan 6, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Yearnchee Curtis WangAlan Varteres Sahakian
Apr 4, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Emre BeslerAlan V Sahakian
Jan 14, 2021·Biomedical Physics & Engineering Express·Duc M NguyenAlistair McEwan
Sep 4, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Chieh-Feng ChangJo-Ping Lee

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