Real-time contrast ultrasound muscle perfusion imaging with intermediate-power imaging coupled with acoustically durable microbubbles

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
Sang-Hoon SeolJonathan R Lindner

Abstract

There is growing interest in limb contrast-enhanced ultrasound (CEU) perfusion imaging for the evaluation of peripheral artery disease. Because of low resting microvascular blood flow in skeletal muscle, signal enhancement during limb CEU is prohibitively low for real-time imaging. The aim of this study was to test the hypothesis that this obstacle can be overcome by intermediate- rather than low-power CEU when performed with an acoustically resilient microbubble agent. Viscoelastic properties of Definity and Sonazoid were assessed by measuring bulk modulus during incremental increases in ambient pressure to 200 mm Hg. Comparison of in vivo microbubble destruction and signal enhancement at a mechanical index (MI) of 0.1 to 0.4 was performed by sequential reduction in pulsing interval from 10 to 0.05 sec during limb CEU at 7 MHz in mice and 1.8 MHz in dogs. Destruction was also assessed by broadband signal generation during passive cavitation detection. Real-time CEU perfusion imaging with destruction-replenishment was then performed at 1.8 MHz in dogs using an MI of 0.1, 0.2, or 0.3. Sonazoid had a higher bulk modulus than Definity (66 ± 12 vs 29 ± 2 kPa, P = .02) and exhibited less inertial cavitation (destruction) at MIs ≥ 0....Continue Reading

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Citations

Mar 16, 2016·Critical Care : the Official Journal of the Critical Care Forum·Sam Orde, Anthony McLean
Dec 17, 2015·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Timothy MurrayMichael J Lee
Nov 27, 2019·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Lauren J DelaneyFlemming Forsberg
May 23, 2020·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Lee-Shuan Lin, Cheng-Shu Chung
Jun 5, 2019·Journal of Cardiovascular Imaging·TheAnh Nguyen, Brian P Davidson
Feb 26, 2019·Vascular and Endovascular Surgery·O MironovGraham Roche-Nagle
Mar 6, 2021·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Lauren J DelaneyGordon R Reeves
Feb 28, 2017·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Brian P DavidsonJonathan R Lindner

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