Real-Time Detection of a Virus Using Detection Dogs

Frontiers in Veterinary Science
T Craig AngleHerris S Maxwell

Abstract

Viral infections are ubiquitous in humans, animals, and plants. Real-time methods to identify viral infections are limited and do not exist for use in harsh or resource-constrained environments. Previous research identified that tissues produce unique volatile organic compounds (VOC) and demonstrated that VOC concentrations change during pathologic states, including infection, neoplasia, or metabolic disease. Patterns of VOC expression may be pathogen specific and may be associated with an odor that could be used for disease detection. We investigated the ability of two trained dogs to detect cell cultures infected with bovine viral diarrhea virus (BVDV) and to discriminate BVDV-infected cell cultures from uninfected cell cultures and from cell cultures infected with bovine herpes virus 1 (BHV 1) and bovine parainfluenza virus 3 (BPIV 3). Dogs were trained to recognize cell cultures infected with two different biotypes of BVDV propagated in Madin-Darby bovine kidney cells using one of three culture media. For detection trials, one target and seven distractors were presented on a scent wheel by a dog handler unaware of the location of targets and distractors. Detection of BVDV-infected cell cultures by Dog 1 had a diagnostic sen...Continue Reading

References

Feb 18, 2006·Integrative Cancer Therapies·Michael McCullochTeresa Janecki
Oct 22, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sandra Van den VeldeMarc Quirynen
Oct 26, 2010·European Urology·Jean-Nicolas CornuOlivier Cussenot
Jul 21, 2011·Journal of Biochemistry·Mika Shirasu, Kazushige Touhara
May 16, 2013·PLoS Pathogens·Lieuwe D J BosMarcus J Schultz
Jul 5, 2013·Clinical Microbiology Reviews·Shneh SethiTrinad Chakraborty
Apr 11, 2014·Chembiochem : a European Journal of Chemical Biology·Alexander A AksenovCristina E Davis
Sep 6, 2014·Journal of Breath Research·Michael SchivoCristina E Davis
Jun 3, 2015·Biomedical Chromatography : BMC·Amir Abd El QaderYehuda Zeiri
Sep 1, 2015·Journal of Biomarkers·Kamila Schmidt, Ian Podmore

❮ Previous
Next ❯

Citations

Jul 26, 2016·Frontiers in Veterinary Science·Craig AngleThomas Passler
Jan 29, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe Lippi, Liam M Heaney
Aug 14, 2020·Journal of Travel Medicine·Robert T JonesJames G Logan
Jul 25, 2020·BMC Infectious Diseases·Paula JendrnyHolger Andreas Volk
Aug 9, 2020·Frontiers in Veterinary Science·Lucia LazarowskiL Paul Waggoner
Feb 7, 2019·Frontiers in Veterinary Science·Astrid R ConchaDaniel S Mills
Aug 24, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Konstantina KatsarouKriton Kalantidis
Apr 20, 2021·Diagnosis·Giuseppe LippiBrandon M Henry
Jun 22, 2021·Journal of Medical Virology·Silvia AngelettiMassimo Ciccozzi
Jul 9, 2021·Frontiers in Veterinary Science·Biagio D'AnielloAnna Scandurra
Aug 21, 2021·BMC Infectious Diseases·Paula JendrnyHolger Andreas Volk
Dec 7, 2021·Frontiers in Medicine·Nele Alexandra Ten HagenHolger Andreas Volk

❮ Previous
Next ❯

Software Mentioned

Excel

Related Concepts