Real-time dopamine efflux in the nucleus accumbens core during Pavlovian conditioning.

Behavioral Neuroscience
Ceyhun Sunsay, George V Rebec

Abstract

To assess the role of dopamine input to the nucleus accumbens core in anticipatory learning, fast-scan cyclic voltammetry was combined with appetitive Pavlovian conditioning. One group of rats (Paired) received 16 tone-food pairings for at least four daily sessions while the control group (Unpaired) received the same number of unpaired tone and food presentations. Both groups showed transient dopamine responses during food presentation throughout training, confirming dopamine involvement in reward processing. Only the Paired Group, however, showed consistently timed dopamine transients during the 10-s tone presentation. Transients first appeared near the end of the tone period as each animal acquired the tone-food association and then occurred progressively sooner on subsequent sessions. Later sessions also revealed a consistently timed dopamine response soon after food delivery in Paired animals. Collectively, these results implicate phasic dopamine release in the acquisition of Pavlovian learning and also suggest an early dopamine response to the unconditioned stimulus as training continues.

References

Aug 25, 1978·Brain Research·R A Wise
Apr 1, 1979·Journal of Experimental Psychology. Animal Behavior Processes·P C Holland
Jul 1, 1988·Analytical Chemistry·J E BaurR M Wightman
Aug 1, 1967·Journal of Comparative and Physiological Psychology·R A Rescorla
Mar 1, 1981·Psychological Review·R S Sutton, A G Barto
Jul 1, 1993·Journal of Neuroscience Methods·K T KawagoeR M Wightman
Mar 14, 1997·Science·W SchultzP R Montague
Aug 15, 1998·Neuropharmacology·W SchultzJ R Hollerman
Aug 10, 2001·Neuroreport·D L RobinsonR M Wightman
Nov 26, 2002·Behavioural Brain Research·Paul A Garris, George V Rebec
Nov 28, 2002·The European Journal of Neuroscience·K P DatlaM H Joseph
Feb 4, 2003·Journal of Experimental Psychology. Animal Behavior Processes·Mark E Bouton, Ceyhun Sunsay
Apr 11, 2003·Nature·Paul E M PhillipsRegina M Carelli
Sep 6, 2003·The European Journal of Neuroscience·J J ChengM G P Feenstra
Feb 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mitchell F RoitmanRegina M Carelli
Jul 1, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wei-Xing PanBrian I Hyland
Apr 15, 2006·CNS & Neurological Disorders Drug Targets·M L A V Heien, R M Wightman
Nov 23, 2006·Nature Reviews. Neuroscience·Peter Redgrave, Kevin Gurney

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Citations

Mar 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Desirae M Haluk, Stan B Floresco
Feb 22, 2012·PLoS Computational Biology·Rodrigo F OliveiraKim T Blackwell
Apr 26, 2011·Advances in Medical Sciences·A J D NelsonH J Cassaday
Mar 27, 2016·Neuroscience and Biobehavioral Reviews·Patrick Anselme
May 6, 2014·Frontiers in Behavioral Neuroscience·Luca Aquili
Jun 28, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J M Wenzel, J F Cheer
Mar 9, 2018·The Behavioral and Brain Sciences·Patrick Anselme, Onur Güntürkün

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