Real-time dose-rate monitoring with gynecologic brachytherapy: Results of an initial clinical trial

Brachytherapy
Matthew D BelleyJunzo P Chino

Abstract

A nanoscintillator-based fiber-optic dosimeter (nanoFOD) was developed to measure real-time dose rate during high-dose-rate (HDR) brachytherapy. A trial was designed to prospectively test clinical feasibility in gynecologic implants. A clinical trial enrolled women undergoing vaginal cylinder HDR brachytherapy. The nanoFOD was fixed to the cylinder alongside two thermoluminescent dosimeters (TLDs). Treatment was delivered and real-time dose rates captured by the nanoFOD. The nanoFOD and TLD positions were identified in CT images and used to extract the treatment planning system (TPS) calculated dose. The nanoFOD and TLD cumulative doses were compared with the TPS. Nine women were enrolled for 30 fractions, and real-time data were available in 27 treatments. The median ratio of nanoFOD/TPS dose was 1.00 (IQR 0.94-1.02), with a TLD/TPS ratio of 1.01 (IQR 0.98-1.04). Of the nanoFOD dose measurements, 63% were within 5% of the TPS, 26% between 5 and 10% of the TPS, and the remaining 11% between 10 and 20% of the TPS dose. Of the TLD measurements, 70% were within 5% of the TPS, 22% between 5 and 10% of the TPS, and 7% between 10 and 20% of the TPS dose. Real-time dose-rate measurements during HDR brachytherapy were feasible using th...Continue Reading

Citations

Jul 16, 2019·Physics in Medicine and Biology·Levi MaddenAnatoly Rosenfeld
Sep 7, 2019·Physics in Medicine and Biology·Gustavo Kertzscher, Sam Beddar
Jul 1, 2020·3D Printing in Medicine·Ergys SubashiOana Craciunescu
Oct 8, 2020·EJNMMI Physics·Liang DingLiang Zhao
Mar 25, 2021·Medical Physics·Hiroaki HayashiTakuya Hashizume

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